General Information:

Id: 1,949
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
BTO:0000011 3T3-L1 cell
article
Reference: Gonzales AM and Orlando RA(2008) Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr Metab (Lond) 5: 17 [PMID: 18549505]

Interaction Information:

Comment Both preadipocytes and differentiated adipocytes express the genes for TNF-alpha, IL-6, and COX-2, key mediators of the inflammatory response. Preadipocytes were also found to express IL-1beta; however, IL-1beta expression was absent in differentiated adipocytes.
Formal Description
Interaction-ID: 15061

gene/protein

IL1B

is_expressed_in

tissue/cell line

preadipocyte

Drugbank entries Show/Hide entries for IL1B
Comment TNF-alpha treatment activates IL-1beta expression in differentiated adipocytes and increases expression of IL-6 and COX-2.
Formal Description
Interaction-ID: 15063

gene/protein

TNF

increases_expression of

gene/protein

IL1B

in adipose tissue, in differentiated adipocytes
Drugbank entries Show/Hide entries for TNF or IL1B
Comment TNF-alpha treatment activates IL-1beta expression in differentiated adipocytes and increases expression of IL-6 and COX-2.
Formal Description
Interaction-ID: 15064

gene/protein

TNF

increases_expression of

gene/protein

IL6

in adipose tissue, in differentiated adipocytes
Drugbank entries Show/Hide entries for TNF or IL6
Comment TNF-alpha treatment activates IL-1beta expression in differentiated adipocytes and increases expression of IL-6 and COX-2.
Formal Description
Interaction-ID: 15065

gene/protein

TNF

increases_expression of

gene/protein

PTGS2

in adipose tissue, in differentiated adipocytes
Drugbank entries Show/Hide entries for TNF or PTGS2
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15066

drug/chemical compound

Curcumin

decreases_activity of

complex/PPI

NF-kappaB complex

in adipose tissue
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15068

drug/chemical compound

Resveratrol

decreases_activity of

complex/PPI

NF-kappaB complex

in adipose tissue
Drugbank entries Show/Hide entries for Resveratrol
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15069

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

TNF

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for TNF
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15070

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

TNF

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol or TNF
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15072

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

IL1B

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for IL1B
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15074

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

IL1B

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol or IL1B
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15076

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

IL6

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for IL6
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15077

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

IL6

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol or IL6
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15078

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

PTGS2

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for PTGS2
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15079

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

PTGS2

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol or PTGS2
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15081

drug/chemical compound

Curcumin

decreases_quantity of

drug/chemical compound

Prostaglandin E2

in adipose tissue; via inhibition of NF-kappaB activation
Comment Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression and a reduction of secreted IL-6 and PGE2.
Formal Description
Interaction-ID: 15082

drug/chemical compound

Resveratrol

decreases_quantity of

drug/chemical compound

Prostaglandin E2

in adipose tissue; via inhibition of NF-kappaB activation
Drugbank entries Show/Hide entries for Resveratrol
Comment Curcumin and resveratrol are able to inhibit TNFalpha-activated NF-kappaB signaling in adipocytes and as a result significantly reduce cytokine expression.
Formal Description
Interaction-ID: 15083

drug/chemical compound

Curcumin

decreases_activity of

in adipose tissue
Comment Curcumin and resveratrol are able to inhibit TNFalpha-activated NF-kappaB signaling in adipocytes and as a result significantly reduce cytokine expression.
Formal Description
Interaction-ID: 15086

drug/chemical compound

Resveratrol

decreases_activity of

in adipose tissue
Drugbank entries Show/Hide entries for Resveratrol
Comment Both preadipocytes and differentiated adipocytes express the genes for TNF-alpha, IL-6, and COX-2, key mediators of the inflammatory response. Preadipocytes were also found to express IL-1beta; however, IL-1beta expression was absent in differentiated adipocytes.
Formal Description
Interaction-ID: 46087

gene/protein

IL1B

NOT is_expressed_in

tissue/cell line

adipocyte

Drugbank entries Show/Hide entries for IL1B