General Information:

Id: 1,914 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Lee M et al.(2010) Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J. 24: 2533-2545 [PMID: 20228251]

Interaction Information:

Comment Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis with BSO causes human microglia, human astrocytes, THP-1 cells, and U373 cells to secrete materials toxic to human neuroblastoma SH-SY5Y cells and stimulates them to release TNF-alpha, IL-6, and nitrite ions.
Formal Description
Interaction-ID: 14800

affects_quantity of

drug/chemical compound

Glutathione

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