General Information:

Id: 1,914 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Lee M et al.(2010) Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J. 24: 2533-2545 [PMID: 20228251]

Interaction Information:

Comment Decreasing intracellular levels of GSH by inhibiting gamma-glutamylcysteine synthetase with BSO induced a neuroinflammatory response in microglia, astrocytes, and the surrogate THP-1 and U373 cell lines, which involved induction of phospho-NF-kappaB, phospho-p38, phospho-JNK and phospho- p42/p44-ERK.
Formal Description
Interaction-ID: 14783

gene/protein

GCLC

affects_quantity of

drug/chemical compound

Glutathione

Drugbank entries Show/Hide entries for GCLC or Glutathione