General Information:

Id: 1,913
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
article
Reference: Hosoi T et al.Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice [PMID: 20824098]

Interaction Information:

Comment MyD88-deficiency exacerbates diabetes without affecting body weight or adiposity.
Formal Description
Interaction-ID: 14673

gene/protein

MYD88

affects_activity of

Comment MyD88-deficiency exacerbates diabetes without affecting body weight or adiposity.
Formal Description
Interaction-ID: 14674

gene/protein

MYD88

NOT affects_activity of

disease

Obesity

Comment As the activation of c-Jun amino-terminal kinase (JNK) in the liver plays a critical role in the development of diabetes, the level of phosphorylated JNK was examined in MyD88-deficient mice. In normal mice fed a high-fat diet an increase in the phosphorylation of JNK was observed, the increase was drastically enhanced in MyD88-deficient mice on the HFD. The result was unexpected because MyD88-deficient mice are resistant to the LPS-induced activation of JNK.
Formal Description
Interaction-ID: 14675

gene/protein

MYD88

affects_activity of

gene/protein

MAPK8

after high-fat diet
Drugbank entries Show/Hide entries for MAPK8
Comment The level of mRNA encoding TNF-alpha was elevated in HFD-fed control mice. However, this increase was markedly inhibited in MyD88-deficient mice on the HFD. Thus, TNF-alpha expression is induced via a MyD88-dependent pathway in mice fed a HFD.
Formal Description
Interaction-ID: 14676

gene/protein

MYD88

affects_expression of

gene/protein

TNF

after high-fat diet
Drugbank entries Show/Hide entries for TNF
Comment The level of mRNA encoding TNF-alpha was elevated in HFD-fed control mice. However, this increase was markedly inhibited in MyD88-deficient mice on the HFD. Thus, TNF-alpha expression is induced via a MyD88-dependent pathway in mice fed a HFD.
Formal Description
Interaction-ID: 14677

affects_expression of

gene/protein

TNF

after high-fat diet
Drugbank entries Show/Hide entries for TNF
Comment The increase of the cholesterol (total, free and esterified cholesterol) levels was markedly higher in MyD88-deficient mice fed the HFD, compared to normal HFD-fed mice.
Formal Description
Interaction-ID: 14678

environment

high-fat diet

increases_quantity of

drug/chemical compound

Cholesterol

Drugbank entries Show/Hide entries for
Comment The increase of the cholesterol (total, free and esterified cholesterol) levels was markedly higher in MyD88-deficient mice fed the HFD, compared to normal HFD-fed mice.
Formal Description
Interaction-ID: 14679

gene/protein

MYD88

affects_quantity of

drug/chemical compound

Cholesterol

after high-fat diet
Drugbank entries Show/Hide entries for
Comment Low density lipoprotein receptor (LDLR) was drastically up-regulated in the liver sample of MyD88-deficient mice fed the HFD, suggesting positive feedback regulation against the increased circulating levels of cholesterols to remove them.
Formal Description
Interaction-ID: 14680

gene/protein

MYD88

affects_quantity of

gene/protein

LDLR

in liver; after high-fat diet
Drugbank entries Show/Hide entries for LDLR
Comment The transcriptional level of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, was up-regulated in the liver sample of MyD88-deficient mice fed the HFD.
Formal Description
Interaction-ID: 14681

gene/protein

MYD88

affects_expression of

gene/protein

HMGCR

in liver; after high-fat diet
Drugbank entries Show/Hide entries for HMGCR
Comment The diabetic phenotype observed in Myd88-deficient mice was due at least in part to increased apoptosis in the liver possibly mediated via hypercholesterolemia.
Formal Description
Interaction-ID: 14682

gene/protein

MYD88

affects_activity of

in liver; after high-fat diet
Comment The serum concentration of alanine aminotransferase (ALT), a marker of hepatic injury, was significantly elevated in MyD88-deficient mice fed the HFD compared with normal mice.
Formal Description
Interaction-ID: 14684

gene/protein

MYD88

affects_quantity of

gene/protein

GPT

after high-fat diet
Drugbank entries Show/Hide entries for GPT