General Information:

Id: 1,893 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Vance JE and Hayashi H(2010) Formation and function of apolipoprotein E-containing lipoproteins in the nervous system Biochim. Biophys. Acta 1801: 806-818 [PMID: 20170744]

Interaction Information:

Comment In fibroblasts, human apo E3-containing HDLs from plasma form a complex with ABCA1, and lipid-free apo E inhibits formation of this complex. The apo E-ABCA1 interaction does not appear to depend on the isoform of apo E since apo E2, apo E3 and apo E4 bind to ABCA1 with similar affinity.
Formal Description
Interaction-ID: 14558

gene/protein mutant

APOE (isoform E4)

interacts (colocalizes) with

gene/protein

ABCA1

Drugbank entries Show/Hide entries for ABCA1