General Information:

Id: 1,893 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Vance JE and Hayashi H(2010) Formation and function of apolipoprotein E-containing lipoproteins in the nervous system Biochim. Biophys. Acta 1801: 806-818 [PMID: 20170744]

Interaction Information:

Comment The APOE isoform E4 allele is also associated with an accelerated development and progression of several other neurodegenerative conditions such as Parkinson's disease, multiple sclerosis, head trauma, cerebral hemorrhage and possibly stroke.
Formal Description
Interaction-ID: 14502

gene/protein mutant

APOE (isoform E4)

increases_activity of

phenotype

neurodegeneration