General Information:

Id: 1,888 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Chung JH et al.(2008) Molecular mechanism of PPAR in the regulation of age-related inflammation Ageing Res. Rev. 7: 126-136 [PMID: 18313368]

Interaction Information:

Comment The activation of PPARG by non-steroid antiinflammatory drugs (NSAIDs) also was shown to suppress pro-inflammatory amyloid-beta in an Alzheimer disease animal model.
Formal Description
Interaction-ID: 14337

drug/chemical compound

NSAID

affects_activity of

gene/protein

PPARG

in an Alzheimer's disease animal model
Drugbank entries Show/Hide entries for PPARG
Comment In support of the involvement of PPAR-gamma in Alzheimer disease, people with long-term intake of PPAR-gamma ligand, certain NSAIDs (Non-steroid antiinflammatory drugs e.g., ibuprofen, indomethacin, naproxen) exhibit reduced risk and manifest delayed development of Alzheimer disease.
Formal Description
Interaction-ID: 14405

drug/chemical compound

NSAID

decreases_activity of