General Information:

Id: 1,888
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Chung JH et al.(2008) Molecular mechanism of PPAR in the regulation of age-related inflammation Ageing Res. Rev. 7: 126-136 [PMID: 18313368]

Interaction Information:

Comment Peroxisome proliferator-activated receptors (PPAR alpha and gamma) activity is closely associated with increased levels of inflammatory mediators during the aging process.
Formal Description
Interaction-ID: 14330

gene/protein

PPARA

affects_activity of

via close association with increased levels of inflammatory mediators during the aging
Drugbank entries Show/Hide entries for PPARA
Comment Peroxisome proliferator-activated receptors (PPAR alpha and gamma) activity is closely associated with increased levels of inflammatory mediators during the aging process.
Formal Description
Interaction-ID: 14331

process

aging

affects_activity of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment Peroxisome proliferator-activated receptors (PPAR alpha and gamma) activity is closely associated with increased levels of inflammatory mediators during the aging process.
Formal Description
Interaction-ID: 14332

process

aging

affects_activity of

gene/protein

PPARG

Drugbank entries Show/Hide entries for PPARG
Comment PPARA and PPARG inhibit the expression of inflammatory genes, such as cytokines, matrix metalloproteases (MMPs), and acute phase proteins.
Formal Description
Interaction-ID: 14335

gene/protein

PPARG

decreases_activity of

by inhibiting the expression of inflammatory genes, such as cytokines, matrix metalloproteases
Drugbank entries Show/Hide entries for PPARG
Comment The activation of PPARG by non-steroid antiinflammatory drugs (NSAIDSs) also was shown to suppress pro-inflammatory amyloid-b in an Alzheimer disease animal model.
Formal Description
Interaction-ID: 14336

gene/protein

PPARG

affects_activity of

gene/protein

Amyloid beta peptide

in an Alzheimer's disease animal model
Drugbank entries Show/Hide entries for PPARG
Comment The activation of PPARG by non-steroid antiinflammatory drugs (NSAIDs) also was shown to suppress pro-inflammatory amyloid-beta in an Alzheimer disease animal model.
Formal Description
Interaction-ID: 14337

drug/chemical compound

NSAID

affects_activity of

gene/protein

PPARG

in an Alzheimer's disease animal model
Drugbank entries Show/Hide entries for PPARG
Comment PPARA and PPARG inhibit the expression of inflammatory genes, such as cytokines, matrix metalloproteases (MMPs), and acute phase proteins.
Formal Description
Interaction-ID: 14339

gene/protein

PPARA

decreases_activity of

by inhibiting the expression of inflammatory genes, such as cytokines, matrix metalloproteases
Drugbank entries Show/Hide entries for PPARA
Comment One contributing factor inherent to age-related oxidative stress of the brain is the presence of microglial cells that are activated by amyloid-beta to produce pro-inflammatory cytokines like IL-1b, IL-6, and TNF-alpha.
Formal Description
Interaction-ID: 14341

gene/protein

Amyloid beta peptide

increases_activity of

Comment One contributing factor inherent to age-related oxidative stress of the brain is the presence of microglial cells that are activated by amyloid-beta to produce pro-inflammatory cytokines like IL-1b, IL-6, and TNF-alpha.
Formal Description
Interaction-ID: 14345

increases_activity of

Comment One contributing factor inherent to age-related oxidative stress of the brain is the presence of microglial cells that are activated by amyloid-beta to produce pro-inflammatory cytokines like IL-1b, IL-6, and TNF-alpha.
Formal Description
Interaction-ID: 14346

increases_expression of

gene/protein

IL1B

if activated by Abeta
Drugbank entries Show/Hide entries for IL1B
Comment One contributing factor inherent to age-related oxidative stress of the brain is the presence of microglial cells that are activated by amyloid-beta to produce pro-inflammatory cytokines like IL-1b, IL-6, and TNF-alpha.
Formal Description
Interaction-ID: 14347

increases_expression of

gene/protein

IL6

if activated by Abeta
Drugbank entries Show/Hide entries for IL6
Comment One contributing factor inherent to age-related oxidative stress of the brain is the presence of microglial cells that are activated by amyloid-beta to produce pro-inflammatory cytokines like IL-1b, IL-6, and TNF-alpha.
Formal Description
Interaction-ID: 14348

increases_expression of

gene/protein

TNF

if activated by Abeta
Drugbank entries Show/Hide entries for TNF
Comment In AD all synapses are encapsulated by cytokine generating glial cells and cytokines are co-localized with senile plaques.
Formal Description
Interaction-ID: 14349

gene/protein

Cytokine

interacts (colocalizes) with

cellular component

synapse

in AD
Comment PPARA and PPARG inhibit the expression of inflammatory genes, such as cytokines, matrix metalloproteases (MMPs), and acute phase proteins.
Formal Description
Interaction-ID: 14355

gene/protein

PPARG

decreases_expression of

gene/protein

Cytokine

Drugbank entries Show/Hide entries for PPARG
Comment PPARA and PPARG inhibit the expression of inflammatory genes, such as cytokines, matrix metalloproteases (MMPs), and acute phase proteins.
Formal Description
Interaction-ID: 14356

gene/protein

PPARA

decreases_expression of

gene/protein

Cytokine

Drugbank entries Show/Hide entries for PPARA
Comment In AD all synapses are encapsulated by cytokine generating glial cells and cytokines are co-localized with senile plaques.
Formal Description
Interaction-ID: 14358

gene/protein

Cytokine

interacts (colocalizes) with

in AD
Comment A correlation between higher concentrations of CRP, IL-6, and TNF-alpha, and greater cognitive declines was found.
Formal Description
Interaction-ID: 14381

phenotype

increased CRP level

cooccurs with

phenotype

increased cognitive impairment

A correlation between higher concentrations of CRP and greater cognitive declines was found.
Comment A correlation between higher concentrations of CRP, IL-6, and TNF-alpha, and greater cognitive declines was found.
Formal Description
Interaction-ID: 14398

phenotype

increased IL6 level

cooccurs with

phenotype

increased cognitive impairment

A correlation between higher concentrations of IL-6 and greater cognitive declines was found.
Comment A correlation between higher concentrations of CRP, IL-6, and TNF-alpha, and greater cognitive declines was found.
Formal Description
Interaction-ID: 14399

phenotype

increased TNF level

cooccurs with

phenotype

increased cognitive impairment

A correlation between higher concentrations of IL-6 and greater cognitive declines was found.
Comment In Alzheimer's disease brains, proinflammatory molecule COX-2 was increased in particulate fraction but not PPAR-gamma level.
Formal Description
Interaction-ID: 14401

affects_quantity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for PTGS2
Comment In Alzheimer's disease brains, proinflammatory molecule COX-2 was increased in particulate fraction but not PPAR-gamma level.
Formal Description
Interaction-ID: 14402

increases_quantity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for PTGS2
Comment In Alzheimer's disease brains, proinflammatory molecule COX-2 was increased in particulate fraction but not PPAR-gamma level.
Formal Description
Interaction-ID: 14403

NOT increases_quantity of

gene/protein

PPARG

Drugbank entries Show/Hide entries for PPARG
Comment Recent studies clearly showed the involvement of PPAR-gamma gene in the pathogenesis of Alzheimer disease.
Formal Description
Interaction-ID: 14404

gene/protein

PPARG

affects_activity of

Drugbank entries Show/Hide entries for PPARG
Comment In support of the involvement of PPAR-gamma in Alzheimer disease, people with long-term intake of PPAR-gamma ligand, certain NSAIDs (Non-steroid antiinflammatory drugs e.g., ibuprofen, indomethacin, naproxen) exhibit reduced risk and manifest delayed development of Alzheimer disease.
Formal Description
Interaction-ID: 14405

drug/chemical compound

NSAID

decreases_activity of

Comment In support of the involvement of PPAR-gamma in Alzheimer disease, people with long-term intake of PPAR-gamma ligand, certain NSAIDs (Non-steroid antiinflammatory drugs e.g., ibuprofen, indomethacin, naproxen) exhibit reduced risk and manifest delayed development of Alzheimer disease.
Formal Description
Interaction-ID: 14406

drug/chemical compound

Ibuprofen

decreases_activity of

Drugbank entries Show/Hide entries for Ibuprofen
Comment In support of the involvement of PPAR-gamma in Alzheimer disease, people with long-term intake of PPAR-gamma ligand, certain NSAIDs (Non-steroid antiinflammatory drugs e.g., ibuprofen, indomethacin, naproxen) exhibit reduced risk and manifest delayed development of Alzheimer disease.
Formal Description
Interaction-ID: 14409

drug/chemical compound

Indomethacin

decreases_activity of

Drugbank entries Show/Hide entries for Indomethacin
Comment In support of the involvement of PPAR-gamma in Alzheimer disease, people with long-term intake of PPAR-gamma ligand, certain NSAIDs (Non-steroid antiinflammatory drugs e.g., ibuprofen, indomethacin, naproxen) exhibit reduced risk and manifest delayed development of Alzheimer disease.
Formal Description
Interaction-ID: 14411

drug/chemical compound

Naproxen

decreases_activity of

Drugbank entries Show/Hide entries for Naproxen