General Information:

Id: 1,884
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Chung HY et al.(2009) Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res. Rev. 8: 18-30 [PMID: 18692159]

Interaction Information:

Comment Hypothesis: Molecular inflammation is a mechanism of aging and age-related pathogenesis. Inflammatory processes are related to the development of dementia, both vascular and Alzheimer's types.
Formal Description
Interaction-ID: 14303

none selected

Drugbank entries Show/Hide entries for or
Comment The immune system is dysregulated with age.
Formal Description
Interaction-ID: 14305

process

aging

decreases_activity of

Comment Aging alters the redox status.
Formal Description
Interaction-ID: 14306

process

aging

affects_activity of

Comment Dysregulation of the immune system with age and altered redox status during aging lead to increases in systemic inflammatory status due to the activation of a wide variety of inflammatory mediators through mainly oxidative stress-induced redox imbalance.
Formal Description
Interaction-ID: 14307

affects_activity of

Comment Dysregulation of the immune system with age and altered redox status during aging lead to increases in systemic inflammatory status due to the activation of a wide variety of inflammatory mediators through mainly oxidative stress-induced redox imbalance.
Formal Description
Interaction-ID: 14311

affects_activity of

Comment Overproduced and unregulated RS during aging are a major causative factor in the activation of immune systems as exemplified in over-reactive macrophages in the inflammatory process.
Formal Description
Interaction-ID: 14315

process

aging

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment Overproduced and unregulated RS during aging are a major causative factor in the activation of immune systems as exemplified in over-reactive macrophages in the inflammatory process.
Formal Description
Interaction-ID: 14318

drug/chemical compound

Reactive oxygen species

affects_activity of

Comment Overproduced and unregulated RS during aging are a major causative factor in the activation of immune systems as exemplified in over-reactive macrophages in the inflammatory process.
Formal Description
Interaction-ID: 14320

affects_activity of