General Information:

Id: 1,867
Diseases: Alzheimer disease - [OMIM]
Tauopathy
Mus musculus
article
Reference: Liu Y et al.(2008) Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimers disease. J. Neurosci. 28 [PMID: 19091971]

Interaction Information:

Comment beta-Amyloid pathology is associated with progressive monoaminergic neurodegeneration in the transgenic mouse model of Alzheimer disease APPswe/PS1deltaE9.
Formal Description
Interaction-ID: 14137

phenotype

beta-amyloid pathology

cooccurs with

phenotype

neurodegeneration

Comment beta-Amyloid pathology is associated with progressive monoaminergic neurodegeneration in the transgenic mouse model of Alzheimer disease APPswe/PS1deltaE9.
Formal Description
Interaction-ID: 14179

phenotype

beta-amyloid pathology

cooccurs with

Comment beta-Amyloid pathology includes Abeta deposits/oligomers and glial reactions.
Formal Description
Interaction-ID: 14180

affects_activity of

phenotype

beta-amyloid pathology

Comment beta-Amyloid pathology includes Abeta deposits/oligomers and glial reactions.
Formal Description
Interaction-ID: 14181

complex/PPI

Amyloid beta peptide (oligomer)

affects_activity of

phenotype

beta-amyloid pathology

Comment beta-Amyloid pathology includes Abeta deposits/oligomers and glial reactions.
Formal Description
Interaction-ID: 14182

phenotype

beta-amyloid pathology

affects_activity of

tissue/cell line

glia

Comment With aging, the Abeta deposition becomes more severe and is associated with astroglial and microglial reactions.
Formal Description
Interaction-ID: 14185

process

aging

increases_quantity of

Comment With aging, the Abeta deposition becomes more severe and is associated with astroglial and microglial reactions.
Formal Description
Interaction-ID: 14186

process

aging

increases_activity of

tissue/cell line

astroglia

Comment With aging, the Abeta deposition becomes more severe and is associated with astroglial and microglial reactions.
Formal Description
Interaction-ID: 14187

process

aging

increases_activity of

tissue/cell line

microglia

Comment Tau pathology includes e.g. hyperphosphorylated tau or neurofibrillary tangles.
Formal Description
Interaction-ID: 14190

cooccurs with

disease

Tauopathy

Comment Tau pathology includes e.g. hyperphosphorylated tau or neurofibrillary tangles.
Formal Description
Interaction-ID: 14191

protein modification

MAPT-hyperphos

increases_activity of

disease

Tauopathy