General Information:

Id: 1,866
Diseases: Bipolar disorder
Mus musculus
article
Reference: OBrien WT and Klein PS(2009) Validating GSK3 as an in vivo target of lithium action. Biochem. Soc. Trans. 37: 1133-1138 [PMID: 19754466]

Interaction Information:

Comment Lithium is widely used to treat bipolar disorder.
Formal Description
Interaction-ID: 14126

drug/chemical compound

Lithium

decreases_activity of

disease

Bipolar disorder

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Comment Lithium directly inhibits GSK3b.
Formal Description
Interaction-ID: 14129

drug/chemical compound

Lithium

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lithium or GSK3B
Comment Lithium also inhibits inositol monophosphatase, several structurally related phosphomonoesterases, phosphoglucomutase and the scaffolding function of beta-arrestin-2.
Formal Description
Interaction-ID: 14135

drug/chemical compound

Lithium

decreases_activity of

gene/protein

ARRB2

Drugbank entries Show/Hide entries for Lithium