General Information:

Id: 1,823 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000258 choroid plexus
article
Reference: Vargas T et al.(2010) Abeta accumulation in choroid plexus is associated with mitochondrial-induced apoptosis Neurobiol. Aging 31: 1569-1581 [PMID: 18838197]

Interaction Information:

Comment A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description
Interaction-ID: 13695

gene/protein

Amyloid beta peptide

affects_quantity of

drug/chemical compound

NO

in AD choroid plexus; when elevated expression of Abeta
Comment A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description
Interaction-ID: 13700

drug/chemical compound

NO

affects_activity of

Comment NO production is increased in choroid plexus of AD subjects and APP/PS1 mic.
Formal Description
Interaction-ID: 13809

increases_quantity of

drug/chemical compound

NO

in choroid plexus
Comment NO production is increased in choroid plexus of AD subjects and APP/PS1 mic.
Formal Description
Interaction-ID: 13810

organism model

APP/PS1 mouse

increases_quantity of

drug/chemical compound

NO

in choroid plexus