General Information:

Id: 1,823 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000258 choroid plexus
Reference: Vargas T et al.(2010) Abeta accumulation in choroid plexus is associated with mitochondrial-induced apoptosis Neurobiol. Aging 31: 1569-1581 [PMID: 18838197]

Interaction Information:

Comment A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description
Interaction-ID: 13700

drug/chemical compound


affects_activity of