General Information:

Id: 1,823
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000258 choroid plexus
article
Reference: Vargas T et al.(2010) Abeta accumulation in choroid plexus is associated with mitochondrial-induced apoptosis Neurobiol. Aging 31: 1569-1581 [PMID: 18838197]

Interaction Information:

Comment Alzheimer patients have an elevated expression of Abeta in the choroid plexus (CP), where it could impair the physiological functions of CP epithelium.
Formal Description
Interaction-ID: 13691

increases_quantity of

in AD choroid plexus
Comment A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description
Interaction-ID: 13695

gene/protein

Amyloid beta peptide

affects_quantity of

drug/chemical compound

NO

in AD choroid plexus; when elevated expression of Abeta
Comment A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description
Interaction-ID: 13700

drug/chemical compound

NO

affects_activity of

Comment A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description
Interaction-ID: 13701

increases_activity of

gene/protein

MMP9

Comment A sequence of pathological steps link Abeta accumulation in CP epithelium with an enhanced nitric oxide production, mitochondrial dysfunction, and up-regulation of matrix metalloproteinase-9, which ultimately lead to cell death, and probably to CSF barrier dysfunction.
Formal Description
Interaction-ID: 13702

gene/protein

MMP9

affects_activity of

process

cell death

Comment The presence of Abeta accumulation in CP of AD brains is associated with transcytosis impairmen.
Formal Description
Interaction-ID: 13704

gene/protein

Amyloid beta peptide

increases_activity of

phenotype

transcytosis impairment

when Abeta is accumulated in CP of AD brains
Comment MMP-9 is increased in CP from AD subjects and APP/PS1 mic.
Formal Description
Interaction-ID: 13806

increases_quantity of

gene/protein

MMP9

in choroid plexus
Comment MMP-9 is increased in CP from AD subjects and APP/PS1 mic.
Formal Description
Interaction-ID: 13807

organism model

APP/PS1 mouse

increases_quantity of

gene/protein

MMP9

in choroid plexus
Comment Abeta (1-42) is associated with hydrogen peroxide levels in choroid plexus epithelial cell.
Formal Description
Interaction-ID: 13808

affects_quantity of

drug/chemical compound

H2O2

in choroid plexus epithelial cells
Comment NO production is increased in choroid plexus of AD subjects and APP/PS1 mic.
Formal Description
Interaction-ID: 13809

increases_quantity of

drug/chemical compound

NO

in choroid plexus
Comment NO production is increased in choroid plexus of AD subjects and APP/PS1 mic.
Formal Description
Interaction-ID: 13810

organism model

APP/PS1 mouse

increases_quantity of

drug/chemical compound

NO

in choroid plexus
Comment Mitochondrial damage is observed in choroid plexus of AD subjects and in vitr.
Formal Description
Interaction-ID: 13811

increases_activity of

in choroid plexus
Comment Abeta (1-42) increases caspase 3 and 9 expression in CP epithelial cell.
Formal Description
Interaction-ID: 13812

increases_expression of

gene/protein

CASP3

in choroid plexus epithelial cells
Drugbank entries Show/Hide entries for CASP3
Comment Abeta (1-42) increases caspase 3 and 9 expression in CP epithelial cell.
Formal Description
Interaction-ID: 13814

increases_expression of

gene/protein

CASP9

in choroid plexus epithelial cells
Comment Cell death is increased in CP of AD subjects and APP/PS1 mic.
Formal Description
Interaction-ID: 13815

increases_activity of

process

cell death

in choroid plexus
Comment Cell death is increased in CP of AD subjects and APP/PS1 mic.
Formal Description
Interaction-ID: 13816

organism model

APP/PS1 mouse

increases_activity of

process

cell death

in choroid plexus;