General Information:

Id: 1,820 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Cui JG et al.(2010) Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease J. Biol. Chem. 285 [PMID: 20937840]

Interaction Information:

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 13649

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

IRAK2