General Information:

Id: 1,820
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Cui JG et al.(2010) Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease J. Biol. Chem. 285 [PMID: 20937840]

Interaction Information:

Comment In 66 control and AD samples a significant up-regulation of miRNA-146a coupled to down-regulation of IRAK-1 and a compensatory up-regulation of IRAK-2 was found.
Formal Description
Interaction-ID: 13629

increases_expression of

ncRNA/miRNA

mir-146a

in IL-1-beta and Abeta42 peptide-stressed HAG cells
Comment In 66 control and AD samples a significant up-regulation of miRNA-146a coupled to down-regulation of IRAK-1 and a compensatory up-regulation of IRAK-2 was found.
Formal Description
Interaction-ID: 13632

affects_expression of

gene/protein

IRAK1

in IL-1-beta and Abeta42 peptide-stressed HAG cells
Comment In 66 control and AD samples a significant up-regulation of miRNA-146a coupled to down-regulation of IRAK-1 and a compensatory up-regulation of IRAK-2 was found.
Formal Description
Interaction-ID: 13633

ncRNA/miRNA

mir-146a

decreases_expression of

gene/protein

IRAK1

in IL-1-beta and Abeta42 peptide-stressed HAG cells
Comment In 66 control and AD samples a significant up-regulation of miRNA-146a coupled to down-regulation of IRAK-1 and a compensatory up-regulation of IRAK-2 was found.
Formal Description
Interaction-ID: 13634

ncRNA/miRNA

mir-146a

increases_expression of

gene/protein

IRAK2

in IL-1-beta and Abeta42 peptide-stressed HAG cells
Comment In 66 control and AD samples a significant up-regulation of miRNA-146a coupled to down-regulation of IRAK-1 and a compensatory up-regulation of IRAK-2 was found.
Formal Description
Interaction-ID: 13636

affects_expression of

gene/protein

IRAK2

in IL-1-beta and Abeta42 peptide-stressed HAG cells
Comment Human astroglial (HAG) cells are stressed by IL-1-beta and Abeta42 peptide.
Formal Description
Interaction-ID: 13637

gene/protein

IL1B

decreases_activity of

tissue/cell line

astroglial cell

Drugbank entries Show/Hide entries for IL1B
Comment Human astroglial (HAG) cells are stressed by IL-1-beta and Abeta42 peptide.
Formal Description
Interaction-ID: 13642

decreases_activity of

tissue/cell line

astroglial cell

Comment Stressed human astroglial (HAG) affect expression of miR-146a.
Formal Description
Interaction-ID: 13644

ncRNA/miRNA

mir-146a

is_expressed_in

tissue/cell line

astroglial cell

if IL-1-beta or Abeta42 peptide-stressed
Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 13649

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

IRAK2

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 13650

drug/chemical compound

Curcumin

decreases_expression of

ncRNA/miRNA

mir-146a

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 13652

drug/chemical compound

Curcumin

increases_expression of

gene/protein

IRAK1

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 13658

drug/chemical compound

CAY10512

decreases_expression of

gene/protein

IRAK2

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 13659

drug/chemical compound

CAY10512

decreases_expression of

ncRNA/miRNA

mir-146a

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 13660

drug/chemical compound

CAY10512

increases_expression of

gene/protein

IRAK1

Comment An NF-kappaB-induced up-regulation of IRAK-2 expression drives an extensively sustained inflammatory response.
Formal Description
Interaction-ID: 13662

gene/protein

NFKB1

increases_expression of

gene/protein

IRAK2

Drugbank entries Show/Hide entries for NFKB1
Comment An NF-kappaB-induced up-regulation of IRAK-2 expression drives an extensively sustained inflammatory response.
Formal Description
Interaction-ID: 13675

gene/protein

IRAK2

increases_activity of

if IRAK-2 is NF-kappaB-induced upregulated
Comment Human astroglial (HAG) cells are stressed by IL-1-beta and Abeta42 peptide.
Formal Description
Interaction-ID: 13677

increases_activity of

Comment Human astroglial (HAG) cells are stressed by IL-1-beta and Abeta42 peptide.
Formal Description
Interaction-ID: 13678

gene/protein

IL1B

increases_activity of

Drugbank entries Show/Hide entries for IL1B
Comment There exists an interactive signaling of NF-kappaB and miRNA-146a.
Formal Description
Interaction-ID: 13680

gene/protein

NFKB1

affects_activity of

ncRNA/miRNA

mir-146a

Drugbank entries Show/Hide entries for NFKB1
Comment There exists an interactive signaling of NF-kappaB and miRNA-146a.
Formal Description
Interaction-ID: 13681

ncRNA/miRNA

mir-146a

affects_activity of

gene/protein

NFKB1

Drugbank entries Show/Hide entries for NFKB1
Comment miRNA-132 showed no increases in AD brains.
Formal Description
Interaction-ID: 13690

NOT increases_quantity of

ncRNA/miRNA

mir-132

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 45588

drug/chemical compound

Pyrrolidine dithiocarbamate

decreases_expression of

gene/protein

IRAK2

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 45589

drug/chemical compound

Pyrrolidine dithiocarbamate

decreases_expression of

ncRNA/miRNA

mir-146a

Comment The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.
Formal Description
Interaction-ID: 45590

drug/chemical compound

Pyrrolidine dithiocarbamate

increases_expression of

gene/protein

IRAK1