General Information:

Id: 177
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) fast-mice
BTO:0000078 microglia ; BTO:0001279 spinal cord
article
Reference: Saxena S et al.(2009) A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice. Nat. Neurosci. 12: 627-636 [PMID: 19330001]

Interaction Information:

Comment In G93A-fast mice, CD11b-positive microglia underwent a rapid morphological change and size expansion between P28 and P32 in lumbar ventral spinal cord.
Formal Description
Interaction-ID: 720

gene/protein mutant

SOD1-p.G93A

increases_activity of

between stage P28 and P32
Comment The stress-protecting factor CNTF effectively attenuated the axonal pathology in VUL motoneurons in mutant G93A-fast-mice.
Formal Description
Interaction-ID: 750

gene/protein

CNTF

decreases_activity of

in mutant SOD1(G93A) fast-mice
Comment Early salubrinal treatment led to low levels of BiP, no evidence of a UPR and no microglial activation at stage P38 and to early signs of a UPR, mild microglial activation and no loss of synaptic vesicles at neuromuscular junctions at stage P53 in mutant SOD1-G93A-fast mice (VUL) motoneurons.
Formal Description
Interaction-ID: 771

drug/chemical compound

Salubrinal

decreases_activity of

in mutant SOD1(G93A) fast-mice