General Information:

Id: 172 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) fast-mice
BTO:0000312 motoneuron (vulnerable)
article
Reference: Saxena S et al.(2009) A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice Nat. Neurosci. 12: 627-636 [PMID: 19330001]

Interaction Information:

Comment Early salubrinal treatment led to low levels of BiP, no evidence of a UPR and no microglial activation at stage P38 and to early signs of a UPR, mild microglial activation and no loss of synaptic vesicles at neuromuscular junctions at stage P53 in mutant SOD1-G93A-fast mice (VUL) motoneurons.
Formal Description
Interaction-ID: 746

drug/chemical compound

Salubrinal

decreases_activity of

in mutant SOD1-G93A-fast mice