General Information:

Id: 172 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) fast-mice
BTO:0000312 motoneuron (vulnerable)
article
Reference: Saxena S et al.(2009) A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice Nat. Neurosci. 12: 627-636 [PMID: 19330001]

Interaction Information:

Comment From stage P32 on, VUL but not RES motoneurons (VUL=vulnerable to motoneuron disease, RES=resistant to) of G93A-fast mice specifically showed an upregulation of unfolded protein response (UPR)-related genes: Eif2a, Atf4, Gadd45, Atf3, Laptm5, Grn, Nrn1, Hexb and Perk.
Formal Description
Interaction-ID: 710

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

EIF2AK3

in motoneurons; from stage P32 on