General Information:

Id: 1,674 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0000011 3T3-L1 cell
article
Reference: Lin Y et al.(2005) The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species J Biol Chem 280: 4617-4626 [PMID: 15536073]

Interaction Information:

Comment Hyperglycemia induced transcriptional changes in 3T3-L1 adipocytes: GMP reductase, mitochondrial capsule selenoprotein, PKC-delta, 6-pyruvoyl-tetrahydropterin synthase, mitochondrial matrix protein P1 precursor, vacuolar ATP synthase, UCP1, calumenin, facilitative glucose transporter GLUT 1, cytochrome c oxidase subunit VIIa-L precursor (Cox7al), Na/K-ATPase alpha 2 subunit, pentraxin PTX3, cytochrome P450, annexin V, Na/K-ATPase beta 1 subunit, and mitochondrial import inner membrane translocase were upregulated, tumor necrosis factor receptor 2, peroxisome proliferator-activated receptor gamma, glutamate dehydrogenase, 6-phosphofructo-2-kinase, lactate dehydrogenase 1, mitochondrial aldehyde dehyrogenase 2, and leptin receptor were downregulated.
Formal Description
Interaction-ID: 12408

phenotype

hyperglycemia

increases_expression of

gene/protein

PRKCD

in adipose tissue
Drugbank entries Show/Hide entries for PRKCD