General Information:

Id: 1,668 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Hepatocellular carcinoma - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
NEMO(L-KO) mouse: mouse with liver-specific inactivation of the NF-kappaB essential modulator gene on high-fat diet
Reference: Wunderlich FT et al.(2008) Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis Proc. Natl. Acad. Sci. U.S.A. 105: 1297-1302 [PMID: 18216263]

Interaction Information:

Comment The inability of the NEMO-deficient liver to up-regulate PPAR-alpha expression contributes to inhibition of beta-oxidation and thus to aggravated storage of triglycerides in hepatocytes.
Formal Description
Interaction-ID: 12302



affects_activity of

in liver