General Information:
Id: | 1,668 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Fatty liver disease, nonalcoholic Hepatocellular carcinoma - [OMIM] Insulin resistance Obesity - [OMIM] |
Mus musculus | |
NEMO(L-KO) mouse: mouse with liver-specific inactivation of the NF-kappaB essential modulator gene on high-fat diet | |
article | |
Reference: | Wunderlich FT et al.(2008) Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis Proc. Natl. Acad. Sci. U.S.A. 105: 1297-1302 [PMID: 18216263] |
Interaction Information:
Comment | The inability of the NEMO-deficient liver to up-regulate PPAR-alpha expression contributes to inhibition of beta-oxidation and thus to aggravated storage of triglycerides in hepatocytes. |
Formal Description Interaction-ID: 12302 |
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