General Information:

Id: 1,665 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
article
Reference: Belgardt BF et al.(2010) Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism Proc. Natl. Acad. Sci. U.S.A. 107: 6028-6033 [PMID: 20231445]

Interaction Information:

Comment Mice with a conditional inactivation of JNK1 in nestin-expressing cells (JNK1(DeltaNES) mice) exhibit improved insulin sensitivity both in the CNS and in peripheral tissues, improved glucose metabolism, as well as protection from hepatic steatosis and adipose tissue dysfunction upon high-fat feeding.
Formal Description
Interaction-ID: 12263

gene/protein

MAPK8

affects_activity of

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