CIDeRGeneral Information:
| Id: | 1,663 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Mus musculus | |
| IL-6Ralpha(L-KO) mouse: mouse with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency | |
| article | |
| Reference: | Wunderlich FT et al.(2010) Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action Cell Metab. 12: 237-249 [PMID: 20816090] |
Interaction Information:
| Comment | In liver IL-6 shows partly counteracting actions on glucose metabolism by simultaneously suppressing enzymes required for gluconeogenesis, glycogenolysis, and glycogen synthesis. Nevertheless, as a consequence of this, the overall effect of IL6 disruption on hepatic glucose metabolism appears largely balanced. |
|
Formal Description Interaction-ID: 12230 |
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| Drugbank entries | Show/Hide entries for IL6 |