General Information:

Id: 1,660
Diseases: Schizophrenia - [OMIM]
Mammalia
review
Reference: Clay HB et al.(2011) Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia Int. J. Dev. Neurosci. 29: 311-324 [PMID: 20833242]

Interaction Information:

Comment In the prefrontal cortex of schizophrenia patients oligodendrocytes showed drastic reductions in mitochondrial number and volume.
Formal Description
Interaction-ID: 12192

disease

Schizophrenia

decreases_quantity of

cellular component

mitochondrion

in the prefrontal cortex
Comment In the prefrontal cortex of schizophrenia patients oligodendrocytes showed drastic reductions in mitochondrial number and volume.
Formal Description
Interaction-ID: 12267

disease

Schizophrenia

affects_activity of

in the prefrontal cortex
Comment SZ patients had also fewer mitochondria in the striatum than controls.
Formal Description
Interaction-ID: 12268

disease

Schizophrenia

decreases_quantity of

cellular component

mitochondrion

in the striatum
Comment Mononuclear cells of SZ patients had enlarged mitochondria with fragmented cristae.
Formal Description
Interaction-ID: 12269

disease

Schizophrenia

affects_activity of

in mononuclear cells
Comment The activated lymphocytes in individuals with SZ had a lower mitochondrial density than controls.
Formal Description
Interaction-ID: 12270

disease

Schizophrenia

decreases_quantity of

cellular component

mitochondrion

in activated lymphocytes
Comment SZ patients showed large reductions in cytochrome c oxidase activity in the caudate nucleus,the frontal cortex and the temporal cortex.
Formal Description
Interaction-ID: 12271

disease

Schizophrenia

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex IV

in the caudate nucleus,the frontal cortex and the temporal cortex
Comment Elevated Ca2+ levels have been detected in peripheral cells from SZ patients.
Formal Description
Interaction-ID: 12295

disease

Schizophrenia

increases_quantity of

drug/chemical compound

Ca2+

in peripheral blood cells
Comment The SZ- associated SNP A3243G,which lies in a mitochondrial leucine-tRNA gene, hampers the tRNAs aminoacylation, resulting in a compensatory up regulation of the leucyl tRNA synthetase LARS2 that was seen both in cybrids containing A3243G and patient brains.
Formal Description
Interaction-ID: 12297

affects_activity of

disease

Schizophrenia

with pathogenic alelle A
Comment The SZ- associated SNP A3243G,which lies in a mitochondrial leucine-tRNA gene, hampers the tRNAs aminoacylation, resulting in a compensatory up regulation of the leucyl tRNA synthetase LARS2 that was seen both in cybrids containing A3243G and patient brains.
Formal Description
Interaction-ID: 12303

gene/protein mutant

MT-TL1-n.A3243G

decreases_activity of

Comment The SZ- associated SNP A3243G,which lies in a mitochondrial leucine-tRNA gene, hampers the tRNAs aminoacylation, resulting in a compensatory up regulation of the leucyl tRNA synthetase LARS2 that was seen both in cybrids containing A3243G and patient brains.
Formal Description
Interaction-ID: 12304

gene/protein mutant

MT-TL1-n.A3243G

increases_expression of

gene/protein

LARS2

Drugbank entries Show/Hide entries for LARS2
Comment An mitochondrial DNA variant observed in SZ, T12027TC results in the change from isoleucine to threonine of the mt-ND4 subunit of NADH-ubiquinone reductase.
Formal Description
Interaction-ID: 12318

gene/protein mutant

MT-ND4-n.T12027TC

affects_activity of

disease

Schizophrenia

Comment The 24-kDa and 51-kDa subunits of mitochondrial respiratory chain complex I were significantly decreased in the prefrontal cortex and in striatum of SZ patients.
Formal Description
Interaction-ID: 12321

disease

Schizophrenia

decreases_expression of

gene/protein

NDUFV2

in prefrontal cortex and in striatum
Drugbank entries Show/Hide entries for NDUFV2
Comment The 24-kDa and 51-kDa subunits of mitochondrial respiratory chain complex I were significantly decreased in the prefrontal cortex and in striatum of SZ patients.
Formal Description
Interaction-ID: 12326

disease

Schizophrenia

decreases_expression of

gene/protein

NDUFV1

in prefrontal cortex and in striatum
Drugbank entries Show/Hide entries for NDUFV1
Comment The mitochondrial complex I activity and expression of the 24-kDa and 51-kDa iron-sulfur flavoprotein subunits were increased in platelets of SZ patients.
Formal Description
Interaction-ID: 12334

disease

Schizophrenia

increases_expression of

gene/protein

NDUFV2

in platelets
Drugbank entries Show/Hide entries for NDUFV2
Comment The mitochondrial complex I activity and expression of the 24-kDa and 51-kDa iron-sulfur flavoprotein subunits were increased in platelets of SZ patients.
Formal Description
Interaction-ID: 12335

disease

Schizophrenia

increases_expression of

gene/protein

NDUFV1

in platelets
Drugbank entries Show/Hide entries for NDUFV1
Comment The level of creatine kinase mRNA was down regulated in the hippocampus and PFC in SZ patients.
Formal Description
Interaction-ID: 12336

disease

Schizophrenia

decreases_expression of

gene/protein

CKMT1A

in hippocampus and in the prefrontal cortex
Drugbank entries Show/Hide entries for CKMT1A
Comment The mitochondrial complex I activity and expression of the 24-kDa and 51-kDa iron-sulfur flavoprotein subunits were increased in platelets of SZ patients.
Formal Description
Interaction-ID: 12349

disease

Schizophrenia

increases_expression of

gene/protein

NDUFV2

in platelets
Drugbank entries Show/Hide entries for NDUFV2
Comment The mitochondrial complex I activity and expression of the 24-kDa and 51-kDa iron-sulfur flavoprotein subunits were increased in platelets of SZ patients.
Formal Description
Interaction-ID: 12350

disease

Schizophrenia

increases_expression of

gene/protein

NDUFV1

in platelets
Drugbank entries Show/Hide entries for NDUFV1
Comment The mitochondrial complex I activity and expression of the 24-kDa and 51-kDa iron-sulfur flavoprotein subunits were increased in platelets of SZ patients.
Formal Description
Interaction-ID: 12587

disease

Schizophrenia

increases_expression of

complex/PPI

Mitochondrial respiratory chain complex I

in platelets
Comment Reduced PME (phosphomonoester) and increased phosphodiester (PDE) levels were observed in the frontal cortex in SZ patients, indicating increased lipid breakdown in the brain.
Formal Description
Interaction-ID: 12609

disease

Schizophrenia

decreases_quantity of

drug/chemical compound

5'-Phosphomonoester

in the frontal cortex
Comment Reduced PME (phosphomonoester) and increased phosphodiester (PDE) levels were observed in the frontal cortex in SZ patients, indicating increased lipid breakdown in the brain.
Formal Description
Interaction-ID: 12621

disease

Schizophrenia

increases_quantity of

drug/chemical compound

Phosphodiester

in the frontal cortex
Comment The positive symptoms of SZ were associated with increased phosphocreatine (PCr) and decreased ATP levels in the right temporal lobe of SZ patients.
Formal Description
Interaction-ID: 12740

phenotype

schizophrenia positive symptoms

affects_quantity of

drug/chemical compound

Phosphocreatine

in the right temporal lobe
Comment The positive symptoms of SZ were associated with increased phosphocreatine (PCr) and decreased ATP levels in the right temporal lobe of SZ patients.
Formal Description
Interaction-ID: 12741

phenotype

schizophrenia positive symptoms

decreases_quantity of

drug/chemical compound

ATP

in the right temporal lobe
Comment The antipsychotic drugs haloperidol and fluphenazine reduced complex I activity in striatum, frontal cortex, hippocampus, and cerebellum.
Formal Description
Interaction-ID: 12742

drug/chemical compound

Haloperidol

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

in striatum, frontal cortex,hippocampus, and cerebellum
Drugbank entries Show/Hide entries for Haloperidol
Comment The antipsychotic drugs haloperidol and fluphenazine reduced complex I activity in striatum, frontal cortex, hippocampus, and cerebellum.
Formal Description
Interaction-ID: 12744

drug/chemical compound

Fluphenazine

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex I

in striatum, frontal cortex, hippocampus, and cerebellum
Drugbank entries Show/Hide entries for Fluphenazine
Comment Treatments with the atypical antipsychotic clozapine,however, did not alter mitochondrial complex I activity.
Formal Description
Interaction-ID: 12745

drug/chemical compound

Clozapine

NOT affects_activity of

complex/PPI

Mitochondrial respiratory chain complex I

Drugbank entries Show/Hide entries for Clozapine