General Information:

Id: 1,654
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse
article
Reference: Stein TD and Johnson JA(2002) Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways J. Neurosci. 22: 7380-7388 [PMID: 12196559]

Interaction Information:

Comment Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APPSw), resulting in high beta-amyloid (Abeta) levels in the brain.
Formal Description
Interaction-ID: 12121

organism model

Tg2576 mouse

increases_expression of

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APPSw), resulting in high beta-amyloid (Abeta) levels in the brain.
Formal Description
Interaction-ID: 12126

organism model

Tg2576 mouse

increases_quantity of

gene/protein

Amyloid beta peptide

in brain
Comment The expression of transthyretin, a protein shown to sequester Abeta and prevent amyloid fibril formation in vitro, and several genes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively in the hippocampus of APPSw mice.
Formal Description
Interaction-ID: 12129

organism model

Tg2576 mouse

increases_expression of

gene/protein

TTR

in hippocampus; 29.5-fold in the hippocampus and 3.2-fold in the cerebellum
Comment Increased expression of transthyretin and insulin-like growth factor-2 and the increased phosphorylation of Bad in hippocampal neurons were maintained in 12-month-old APPSw mice when compared with age-matched controls.
Formal Description
Interaction-ID: 12138

organism model

Tg2576 mouse

increases_expression of

gene/protein

IGF2

in hippocampal neurons; in 12-month-old APPSw mice
Comment Increased expression of transthyretin and insulin-like growth factor-2 and the increased phosphorylation of Bad in hippocampal neurons were maintained in 12-month-old APPSw mice when compared with age-matched controls.
Formal Description
Interaction-ID: 12139

organism model

Tg2576 mouse

increases_phosphorylation of

gene/protein

BAD

in hippocampal neurons; in 12-month-old APPSw mice
Comment Differentially regulated genes in the hippocampus of APPSw mice: the aging gene, klotho, was increased more than sixfold.
Formal Description
Interaction-ID: 12158

organism model

Tg2576 mouse

increases_expression of

gene/protein

KL

more than sixfold
Comment Differentially regulated genes in the hippocampus of APPSw mice: the aging gene, klotho, was increased more than sixfold.
Formal Description
Interaction-ID: 12159

process

aging

increases_quantity of

gene/protein

KL

Comment Transthyretin is the major Abeta binding protein in the CSF and inhibits Abeta aggregation and fibril formation in vitro.
Formal Description
Interaction-ID: 12160

gene/protein

TTR

decreases_quantity of

in hippocampus and cerebellum
Comment Transthyretin is the major Abeta binding protein in the CSF and inhibits Abeta aggregation and fibril formation in vitro.
Formal Description
Interaction-ID: 12161

gene/protein

TTR

decreases_folding of

gene/protein

Amyloid beta peptide

in hippocampus and cerebellum
Comment c-fos and mitogenactivated protein kinase kinase kinase 4 (MEKK4b), involved in apoptosis, are decreased in APPsw mice.
Formal Description
Interaction-ID: 12162

organism model

Tg2576 mouse

decreases_expression of

gene/protein

FOS

in hippocampus and cerebellum
Drugbank entries Show/Hide entries for FOS
Comment c-fos and mitogenactivated protein kinase kinase kinase 4 (MEKK4), involved in apoptosis, are decreased in APPsw mice.
Formal Description
Interaction-ID: 12163

organism model

Tg2576 mouse

decreases_expression of

gene/protein

MAP3K4

in hippocampus
Comment c-fos and mitogenactivated protein kinase kinase kinase 4 (MEKK4), involved in apoptosis, are decreased in APPsw mice.
Formal Description
Interaction-ID: 12165

gene/protein

MAP3K4

affects_activity of

Comment c-fos and mitogenactivated protein kinase kinase kinase 4 (MEKK4b), involved in apoptosis, are decreased in APPsw mice.
Formal Description
Interaction-ID: 12166

gene/protein

FOS

affects_activity of

Drugbank entries Show/Hide entries for FOS
Comment Differentially regulated genes in the hippocampus of APPSw mice: Protein phosphatase 1B magnesium-dependent beta isoform.
Formal Description
Interaction-ID: 12170

organism model

Tg2576 mouse

decreases_expression of

gene/protein

PPM1B

in hippocampus
Comment Protein phosphatase 1B magnesium-dependent beta isoform is involved in apoptosis events.
Formal Description
Interaction-ID: 12171

gene/protein

PPM1B

affects_activity of

Comment Differentially regulated genes in the hippocampus of APPSw mice: Decorin is involved in extracellular matrix and tissue remodeling.
Formal Description
Interaction-ID: 12173

organism model

Tg2576 mouse

increases_expression of

gene/protein

DCN

in hippocampus
Drugbank entries Show/Hide entries for DCN
Comment Differentially regulated genes in the hippocampus of APPSw mice: IGF-2 expression is increased.
Formal Description
Interaction-ID: 12176

organism model

Tg2576 mouse

increases_expression of

gene/protein

IGF2

in hippocampus
Comment Differentially regulated genes in the hippocampus of APPSw mice: ectonucleotide pyrophosphatase / phosphodiesterase 2 is increased in cerebellum.
Formal Description
Interaction-ID: 12178

organism model

Tg2576 mouse

increases_expression of

gene/protein

ENPP2

in cerebellum
Comment Differentially regulated genes in the hippocampus of APPSw mice: IGFBP-2 is increased in hippocampus.
Formal Description
Interaction-ID: 12179

organism model

Tg2576 mouse

increases_expression of

gene/protein

IGFBP2

in hippocampus
Comment Differentially regulated genes in the hippocampus of APPSw mice: growth hormone receptor is increased in hippocampus.
Formal Description
Interaction-ID: 12180

organism model

Tg2576 mouse

increases_expression of

gene/protein

GHR

in hippocampus
Drugbank entries Show/Hide entries for GHR
Comment Differentially regulated genes in the hippocampus of APPSw mice: prolactin receptor is increased in hippocampus.
Formal Description
Interaction-ID: 12182

organism model

Tg2576 mouse

increases_expression of

gene/protein

PRLR

in hippocampus
Drugbank entries Show/Hide entries for PRLR
Comment The level of tyrosine-phosphorylated IGF-1Rbeta is increased in the hippocampus when compared with control animals.
Formal Description
Interaction-ID: 12186

organism model

Tg2576 mouse

increases_expression of

gene/protein

IGF1

in hippocampus
Drugbank entries Show/Hide entries for IGF1
Comment Phospho-Akt was within the nucleus of hippocampal neurons in APPSw mice.
Formal Description
Interaction-ID: 12199

protein modification

AKT1-phos

is localized in

cellular component

nucleus

in hippocampal neurons; in APPSw mouse
Comment Phospho-Erk1/2 is found predominantly in the nucleus of neurons.
Formal Description
Interaction-ID: 12212

protein modification

MAPK1-phos

is localized in

cellular component

nucleus

of neurons
Comment Phospho-Erk1/2 is found predominantly in the nucleus of neurons.
Formal Description
Interaction-ID: 12217

protein modification

MAPK3-phos

increases_activity of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for MAPK3
Comment Phospho-Erk1/2 is found predominantly in the nucleus of neurons.
Formal Description
Interaction-ID: 12219

protein modification

MAPK1-phos

increases_activity of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for MAPK1
Comment Folate binding protein 1 is increased in the hippocampus of APPSw mice and acts as a receptor to mediate the delivery of 5-methyltetrahydrofolate to the interior of cells.
Formal Description
Interaction-ID: 12265

organism model

Tg2576 mouse

increases_quantity of

gene/protein

FOLR1

in hippocampus
Comment Folate binding protein 1 is increased in the hippocampus of APPSw mice and acts as a receptor to mediate the delivery of 5-methyltetrahydrofolate to the interior of cells.
Formal Description
Interaction-ID: 12266

gene/protein

FOLR1

affects transport of

drug/chemical compound

5-Methyltetrahydrofolate

in hippocampus; into cells
Drugbank entries Show/Hide entries for
Comment Chloride channel protein 3 (CLCN3) was decreased in the hippocampus of APPSw mice.
Formal Description
Interaction-ID: 12272

organism model

Tg2576 mouse

decreases_quantity of

gene/protein

CLCN3

Comment Differentially regulated genes in the hippocampus of APPSw mice: Peroxiredoxin 2 expression is increased.
Formal Description
Interaction-ID: 12277

organism model

Tg2576 mouse

increases_expression of

gene/protein

PRDX2

in cerebellum
Drugbank entries Show/Hide entries for PRDX2
Comment Differentially regulated genes in the hippocampus of APPSw mice: Syntaxin 4 expression is increased.
Formal Description
Interaction-ID: 12278

organism model

Tg2576 mouse

increases_expression of

gene/protein

STX4

in cerebellum
Comment Differentially regulated genes in the hippocampus of APPSw mice: Eph receptor A7expression is increased.
Formal Description
Interaction-ID: 12280

organism model

Tg2576 mouse

increases_expression of

gene/protein

EPHA7

in cerebellum
Drugbank entries Show/Hide entries for EPHA7
Comment Transthyretin is the major Abeta binding protein in the CSF and inhibits Abeta aggregation and fibril formation in vitro.
Formal Description
Interaction-ID: 32915

gene/protein

TTR

decreases_quantity of