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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	1,648 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance Obesity - [OMIM]
Organism:	Mus musculus
Organism Model:	Pten(DeltaObRb) mouse: selective Pten ablation in leptin-sensitive neurons
Publication type:	article
Reference:	Plum L et al.(2007) Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation Cell Metab. 6: 431-445 [PMID: 18054313]

Interaction Information:

Comment	Leptin-stimulated Pi3k signaling in the CNS regulates energy expenditure via activation of SNA to perigonadal WAT leading to BAT-like differentiation of WAT.
Formal Description Interaction-ID: 12123	gene/protein LEP increases_activity of process phosphatidylinositol 3-kinase signaling in central nervous system

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