General Information:
Id: | 1,648 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
Mus musculus | |
Pten(DeltaObRb) mouse: selective Pten ablation in leptin-sensitive neurons | |
article | |
Reference: | Plum L et al.(2007) Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation Cell Metab. 6: 431-445 [PMID: 18054313] |
Interaction Information:
Comment | Leptin-stimulated Pi3k signaling in the CNS regulates energy expenditure via activation of SNA to perigonadal WAT leading to BAT-like differentiation of WAT. |
Formal Description Interaction-ID: 12123 |
gene/protein increases_activity of |