General Information:

Id: 1,648 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
Pten(DeltaObRb) mouse: selective Pten ablation in leptin-sensitive neurons
article
Reference: Plum L et al.(2007) Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation Cell Metab. 6: 431-445 [PMID: 18054313]

Interaction Information:

Comment Leptin-stimulated Pi3k signaling in the CNS regulates energy expenditure via activation of SNA to perigonadal WAT leading to BAT-like differentiation of WAT.
Formal Description
Interaction-ID: 12123

gene/protein

LEP

increases_activity of

process

phosphatidylinositol 3-kinase signaling

in central nervous system