General Information:

Id: 1,634 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
mouse expressing a constitutively active version of Stat3 (Stat3-C) in proopiomelanocortin (POMC) neurons (Stat3-C(POMC) mouse)
Reference: Ernst MB et al.(2009) Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity J. Neurosci. 29 [PMID: 19759305]

Interaction Information:

Comment POMC-cell-specific, Stat3-mediated upregulation of SOCS3 expression inhibits both leptin and insulin signaling as insulin-stimulated PIP(3) (phosphatidylinositol-3,4,5 triphosphate) formation and protein kinase B (AKT) activation in POMC neurons.
Formal Description
Interaction-ID: 12027



decreases_activity of

in POMC neurons