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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
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COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
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Farber lipogranulomatosis
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	Field	Term

General Information:

Id:	1,634 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance Obesity - [OMIM]
Organism:	Mus musculus
Organism Model:	mouse expressing a constitutively active version of Stat3 (Stat3-C) in proopiomelanocortin (POMC) neurons (Stat3-C(POMC) mouse)
Publication type:	article
Reference:	Ernst MB et al.(2009) Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity J. Neurosci. 29 [PMID: 19759305]

Interaction Information:

Comment	POMC-cell-specific, Stat3-mediated upregulation of SOCS3 expression inhibits both leptin and insulin signaling as insulin-stimulated PIP(3) (phosphatidylinositol-3,4,5 triphosphate) formation and protein kinase B (AKT) activation in POMC neurons.
Formal Description Interaction-ID: 12027	gene/protein SOCS3 decreases_activity of process insulin receptor signaling pathway in POMC neurons

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