General Information:

Id: 1,627
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Hill JW et al.(2008) Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice J. Clin. Invest. 118: 1796-1805 [PMID: 18382766]

Interaction Information:

Comment A PI3K-dependent mechanism is required for the leptin-induced activation of proopiomelanocortin (POMC) neurons, which are located in the arcuate nucleus (ARC) of the hypothalamus.
Formal Description
Interaction-ID: 11917

gene/protein

LEP

increases_activity of

tissue/cell line

POMC-expressing neuron

in the arcuate nucleus of the hypothalamus; via PI3K
Comment A PI3K-dependent mechanism is required for the leptin-induced activation of proopiomelanocortin (POMC) neurons, which are located in the arcuate nucleus (ARC) of the hypothalamus.
Formal Description
Interaction-ID: 11918

complex/PPI

Phosphatidylinositol 3-kinase

affects_activity of

tissue/cell line

POMC-expressing neuron

in the arcuate nucleus of the hypothalamus
Comment Targeted POMC PI3K deletion disrupts insulin and leptin effects on neuronal activity.
Formal Description
Interaction-ID: 11919

complex/PPI

Phosphatidylinositol 3-kinase

affects_activity of

in POMC neurons
Comment Targeted POMC PI3K deletion disrupts insulin and leptin effects on neuronal activity.
Formal Description
Interaction-ID: 11949

complex/PPI

Phosphatidylinositol 3-kinase

affects_activity of

in POMC neurons
Comment PI3K signaling in POMC neurons is not a major contributor to the regulation of long-term organismal energy homeostasis.
Formal Description
Interaction-ID: 11950

NOT affects_activity of

process

long-term regulation of energy homeostasis