General Information:

Id: 1,625
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
neural-specific STAT3 deletion (STAT3N-/-)
article
Reference: Gao Q et al.(2004) Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation Proc. Natl. Acad. Sci. U.S.A. 101: 4661-4666 [PMID: 15070774]

Interaction Information:

Comment Mice with a neural-specific disruption of STAT3 (STAT3(N-/-)) were created, homozygous mutants were born at the expected Mendelian ratio without apparent developmental abnormalities but susceptible to neonatal lethality. Mutants that survived the neonatal period were hyperphagic, obese, diabetic, and infertile.
Formal Description
Interaction-ID: 11900

gene/protein

STAT3

affects_activity of

disease

Obesity

Comment Mice with a neural-specific disruption of STAT3 (STAT3(N-/-)) were created, homozygous mutants were born at the expected Mendelian ratio without apparent developmental abnormalities but susceptible to neonatal lethality. Mutants that survived the neonatal period were hyperphagic, obese, diabetic, and infertile.
Formal Description
Interaction-ID: 11901

gene/protein

STAT3

affects_activity of

Comment Mice with a neural-specific disruption of STAT3 (STAT3(N-/-)) were created, homozygous mutants were born at the expected Mendelian ratio without apparent developmental abnormalities but susceptible to neonatal lethality. Mutants that survived the neonatal period were hyperphagic, obese, diabetic, and infertile.
Formal Description
Interaction-ID: 11902

gene/protein

STAT3

affects_activity of

phenotype

infertility

Comment The livers of mice with neural-specific STAT3 deletion (STAT3N-/-) were severely enlarged with greatly increased fat deposits despite no local defect of STAT3, in contrast, a hepatocyte-specific knockout of STAT3 under the same diet did not result in increased fat deposits in the liver.
Formal Description
Interaction-ID: 11903

gene/protein

STAT3

affects_quantity of

tissue/cell line

liver

Comment STAT3N-/- animals have reduced energy expenditure.
Formal Description
Interaction-ID: 11907

gene/protein

STAT3

affects_activity of

Comment STAT3(N-/-) mice are hyperleptinemic, suggesting a leptin-resistant condition.
Formal Description
Interaction-ID: 11909

gene/protein

STAT3

affects_quantity of

gene/protein

LEP

Comment STAT3(N-/-) mice are hyperleptinemic, suggesting a leptin-resistant condition.
Formal Description
Interaction-ID: 11910

gene/protein

STAT3

affects_activity of

Comment STAT3N-/- animals have reduced energy expenditure.
Formal Description
Interaction-ID: 11912

gene/protein

STAT3

affects_activity of

Comment STAT3 in the CNS plays essential roles in the regulation of energy homeostasis and reproduction.
Formal Description
Interaction-ID: 11913

gene/protein

STAT3

affects_activity of

Comment STAT3 in the CNS plays essential roles in the regulation of energy homeostasis and reproduction.
Formal Description
Interaction-ID: 11916

gene/protein

STAT3

affects_activity of

process

reproduction