General Information:

Id: 1,610
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
female
article
Reference: Birsoy K et al.(2008) Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach Proc. Natl. Acad. Sci. U.S.A. 105 [PMID: 18753616]

Interaction Information:

Comment Weight loss induced by fasting or leptin treatment results in the retention of lipid-depleted adipocytes in adipose depots.
Formal Description
Interaction-ID: 11792

environment

fasting

decreases_quantity of

drug/chemical compound

Lipid

in adipocytes
Comment Weight loss induced by fasting or leptin treatment results in the retention of lipid-depleted adipocytes in adipose depots.
Formal Description
Interaction-ID: 11799

environment

fasting

NOT decreases_quantity of

tissue/cell line

adipocyte

in adipose tissue
Comment Weight loss induced by fasting or leptin treatment results in the retention of lipid-depleted adipocytes in adipose depots.
Formal Description
Interaction-ID: 11801

gene/protein

LEP

decreases_quantity of

drug/chemical compound

Lipid

in adipocytes
Comment Weight loss induced by fasting or leptin treatment results in the retention of lipid-depleted adipocytes in adipose depots.
Formal Description
Interaction-ID: 11802

gene/protein

LEP

NOT decreases_quantity of

tissue/cell line

adipocyte

in adipose tissue
Comment To further study the cellular response to weight regain after leptin treatment, a leptin withdrawal protocol was used to induce a state of acute leptin deficiency in wild type mice. Acute leptin deficiency led to the transient deposition of large amounts of glycogen within pre-existing, lipid-depleted adipocytes. This was followed by rapid reaccumulation of lipid.
Formal Description
Interaction-ID: 11808

increases_quantity of

drug/chemical compound

Glycogen

in adipocytes
Comment An acute decrease in circulating leptin level induced nearly the entire complement of genes necessary to increase simple sugar flux into the adipocyte, and subsequently convert these sugars into cytosolic acetyl-CoA and glycerol for de novo fatty acid, triglyceride, and cholesterol biosynthesis.
Formal Description
Interaction-ID: 11836

increases_quantity of

drug/chemical compound

Acetyl-CoA

in cytosol of adipocytes
Comment An acute decrease in circulating leptin level induced nearly the entire complement of genes necessary to increase simple sugar flux into the adipocyte, and subsequently convert these sugars into cytosolic acetyl-CoA and glycerol for de novo fatty acid, triglyceride, and cholesterol biosynthesis.
Formal Description
Interaction-ID: 11838

increases_quantity of

drug/chemical compound

Glycerol

in cytosol of adipocytes
Drugbank entries Show/Hide entries for
Comment An acute decrease in circulating leptin level induced nearly the entire complement of genes necessary to increase simple sugar flux into the adipocyte, and subsequently convert these sugars into cytosolic acetyl-CoA and glycerol for de novo fatty acid, triglyceride, and cholesterol biosynthesis.
Formal Description
Interaction-ID: 11839

increases_activity of

in adipose tissue
Comment An acute decrease in circulating leptin level induced nearly the entire complement of genes necessary to increase simple sugar flux into the adipocyte, and subsequently convert these sugars into cytosolic acetyl-CoA and glycerol for de novo fatty acid, triglyceride, and cholesterol biosynthesis.
Formal Description
Interaction-ID: 11841

increases_activity of

in adipose tissue
Comment An acute decrease in circulating leptin level induced nearly the entire complement of genes necessary to increase simple sugar flux into the adipocyte, and subsequently convert these sugars into cytosolic acetyl-CoA and glycerol for de novo fatty acid, triglyceride, and cholesterol biosynthesis.
Formal Description
Interaction-ID: 11842

increases_activity of

in adipose tissue
Comment Leptin withdrawal induced the expression of genes required for the storage of cytoplasmic triglycerides, including genes involved in the synthesis of glycerol, such as glycerol-3-phosphate dehydrogenase mRNA.
Formal Description
Interaction-ID: 11843

increases_activity of

in adipose tissue
Comment Leptin withdrawal induced the expression of genes required for the storage of cytoplasmic triglycerides, including genes involved in the synthesis of glycerol, such as glycerol-3-phosphate dehydrogenase mRNA.
Formal Description
Interaction-ID: 11844

increases_expression of

gene/protein

GPD1

in adipose tissue
Drugbank entries Show/Hide entries for GPD1
Comment Acute leptin deficiency repressed carnitine-palmitoyl transferase-I (CPT-I) and peroxisomal acyl-CoA oxidase (ACO), both of which are required for fatty acid oxidation and white adipose phosphoenolpyruvate carboxykinase mRNA, which would detract from acetyl-CoA accumulation.
Formal Description
Interaction-ID: 11846

decreases_expression of

gene/protein

CPT1A

Drugbank entries Show/Hide entries for CPT1A
Comment Acute leptin deficiency repressed carnitine-palmitoyl transferase-I (CPT-I) and peroxisomal acyl-CoA oxidase (ACO), both of which are required for fatty acid oxidation and white adipose phosphoenolpyruvate carboxykinase mRNA, which would detract from acetyl-CoA accumulation.
Formal Description
Interaction-ID: 11852

decreases_expression of

gene/protein

ACOX

Comment Acute leptin deficiency repressed carnitine-palmitoyl transferase-I (CPT-I) and peroxisomal acyl-CoA oxidase (ACO), both of which are required for fatty acid oxidation and white adipose phosphoenolpyruvate carboxykinase mRNA, which would detract from acetyl-CoA accumulation.
Formal Description
Interaction-ID: 11853

decreases_activity of

Comment Acute leptin deficiency repressed carnitine-palmitoyl transferase-I (CPT-I) and peroxisomal acyl-CoA oxidase (ACO), both of which are required for fatty acid oxidation and white adipose phosphoenolpyruvate carboxykinase mRNA, which would detract from acetyl-CoA accumulation.
Formal Description
Interaction-ID: 11856

decreases_expression of

gene/protein

PCK1

in adipose tissue
Drugbank entries Show/Hide entries for PCK1
Comment Leptin withdrawal did not regulate the mRNA of genes involved in glycogen synthesis or glycogenolysis, suggesting that the induction of glycogen synthesis is not regulated at the level of transcription.
Formal Description
Interaction-ID: 11861

NOT affects_quantity of

drug/chemical compound

Glycogen

via mRNA expression level
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11863

increases_expression of

gene/protein

SLC2A4

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11866

increases_expression of

gene/protein

SLC2A5

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11867

increases_expression of

gene/protein

HK1

Drugbank entries Show/Hide entries for HK1
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11868

increases_expression of

gene/protein

HK2

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11869

increases_expression of

gene/protein

GPI

Drugbank entries Show/Hide entries for GPI
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11870

increases_expression of

gene/protein

MPI

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11871

increases_expression of

gene/protein

PFKM

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11872

increases_expression of

gene/protein

ALDO

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11873

increases_expression of

gene/protein

GPD1

Drugbank entries Show/Hide entries for GPD1
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11874

increases_expression of

gene/protein

TPI1

Drugbank entries Show/Hide entries for TPI1
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11875

increases_expression of

gene/protein

GAPDH

Drugbank entries Show/Hide entries for GAPDH
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11876

increases_expression of

gene/protein

PGK1

Drugbank entries Show/Hide entries for PGK1
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11877

increases_expression of

gene/protein

PGAM

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11878

increases_expression of

gene/protein

ENO1

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporte.
Formal Description
Interaction-ID: 11879

increases_expression of

gene/protein

Pyruvate kinase

Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11880

increases_expression of

gene/protein

DLAT

Drugbank entries Show/Hide entries for DLAT
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11881

increases_expression of

gene/protein

CS

Drugbank entries Show/Hide entries for CS
Comment The following acetyl-CoA and glycerol generating enzymes were up-regulated by acute leptin deficiency: GLUT4, GLUT5, hexokinase, hexokinase II, G-6-P isomerase, M-6-P isomerase, PFK-1, aldolase, glycerol-3-P dehydrogenase, TPI, GAPDH, phosphoglycerate kinase, phosphoglycerate mutase, alpha-enolase, pyruvate kinase, pyruvate dehydrogenase complex E2, citrate synthase, and citrate transporter.
Formal Description
Interaction-ID: 11884

increases_expression of

gene/protein

SLC25A1