General Information:

Id: 1,598 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0003292 RAW-264.7 cell
article
Reference: Hong Byun E et al.(2010) TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor J. Immunol. 185: 33-45 [PMID: 20511545]

Interaction Information:

Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11666

drug/chemical compound

Lipopolysaccharide

increases_quantity of

drug/chemical compound

NO

in peritoneal macrophages
Comment The production of TNF-alpha, IL-6 and NO was significantly increased in culture supernatant from murine peritoneal macrophages upon treatment with LPS and the LPS-induced production of these inflammatory mediators was significantly inhibited by EGCG treatment.
Formal Description
Interaction-ID: 11671

drug/chemical compound

Epigallocatechin 3-gallate

decreases_quantity of

drug/chemical compound

NO

in peritoneal macrophages; after LPS treatment