General Information:

Id: 1,592 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000195 CACO-2 cell
article
Reference: Sergent T et al.(2010) Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium Chem. Biol. Interact. 188: 659-667 [PMID: 20816778]

Interaction Information:

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11541

decreases_expression of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment In Caco-2 cells incubated with chrysin the expression of IL1B, IL1R1, PPARA, ABCG2, FADS2, SCD, and SC5DL is significantly downregulated.
Formal Description
Interaction-ID: 11569

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment NFKB1, NFKB2, STAT3, PPAR alpha, and SREBF1 are transcription factors.
Formal Description
Interaction-ID: 11639

gene/protein

PPARA

affects_activity of

Drugbank entries Show/Hide entries for PPARA
Comment NFKB1, NFKB2, STAT3, PPAR alpha, and SREBF1 are transcription factors.
Formal Description
Interaction-ID: 11640

gene/protein

PPARA

affects_activity of

Drugbank entries Show/Hide entries for PPARA