General Information:

Id: 1,592
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000195 CACO-2 cell
article
Reference: Sergent T et al.(2010) Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium Chem. Biol. Interact. 188: 659-667 [PMID: 20816778]

Interaction Information:

Comment To mimic intestinal inflammation, differentiated Caco-2 cells cultivated in bicameral inserts, in a serum-free medium, were treated with a cocktail of pro-inflammatory substances: interleukin (IL)-beta, tumor necrosis factor-alpha, interferon-gamma and lipopolysaccharides. In inflamed cells, the incubation with genistein reduced the IL-6 and MCP-1 overproduction, to ca. 50% of the control, whereas EGCG provoked a decrease in the IL-6 and IL-8 over-secretion, by 50 and 60%, respectively.
Formal Description
Interaction-ID: 11501

drug/chemical compound

Genistein

decreases_quantity of

gene/protein

IL6

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or IL6
Comment To mimic intestinal inflammation, differentiated Caco-2 cells cultivated in bicameral inserts, in a serum-free medium, were treated with a cocktail of pro-inflammatory substances: interleukin (IL)-beta, tumor necrosis factor-alpha, interferon-gamma and lipopolysaccharides. In inflamed cells, the incubation with genistein reduced the IL-6 and MCP-1 overproduction, to ca. 50% of the control, whereas EGCG provoked a decrease in the IL-6 and IL-8 over-secretion, by 50 and 60%, respectively.
Formal Description
Interaction-ID: 11512

drug/chemical compound

Genistein

decreases_quantity of

gene/protein

CCL2

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or CCL2
Comment To mimic intestinal inflammation, differentiated Caco-2 cells cultivated in bicameral inserts, in a serum-free medium, were treated with a cocktail of pro-inflammatory substances: interleukin (IL)-beta, tumor necrosis factor-alpha, interferon-gamma and lipopolysaccharides. In inflamed cells, the incubation with genistein reduced the IL-6 and MCP-1 overproduction, to ca. 50% of the control, whereas EGCG provoked a decrease in the IL-6 and IL-8 over-secretion, by 50 and 60%, respectively.
Formal Description
Interaction-ID: 11513

drug/chemical compound

Epigallocatechin 3-gallate

decreases_quantity of

gene/protein

IL6

in inflamed cells
Drugbank entries Show/Hide entries for IL6
Comment To mimic intestinal inflammation, differentiated Caco-2 cells cultivated in bicameral inserts, in a serum-free medium, were treated with a cocktail of pro-inflammatory substances: interleukin (IL)-beta, tumor necrosis factor-alpha, interferon-gamma and lipopolysaccharides. In inflamed cells, the incubation with genistein reduced the IL-6 and MCP-1 overproduction, to ca. 50% of the control, whereas EGCG provoked a decrease in the IL-6 and IL-8 over-secretion, by 50 and 60%, respectively.
Formal Description
Interaction-ID: 11514

drug/chemical compound

Epigallocatechin 3-gallate

decreases_quantity of

gene/protein

CXCL8

in inflamed cells
Comment All the phenolic compounds generated a specific gene expression profile, with genistein the most efficient in the downregulation of the expression, or over-expression, of inflammatory genes notably those linked to the arachidonic metabolism pathway. Genistein and EGCG downregulate the inflammatory response in inflamed intestinal epithelial cells by a pathway implicating largely a post-transcriptional regulatory mechanism.
Formal Description
Interaction-ID: 11515

drug/chemical compound

Genistein

decreases_activity of

Drugbank entries Show/Hide entries for Genistein
Comment All the phenolic compounds generated a specific gene expression profile, with genistein the most efficient in the downregulation of the expression, or over-expression, of inflammatory genes notably those linked to the arachidonic metabolism pathway. Genistein and EGCG downregulate the inflammatory response in inflamed intestinal epithelial cells by a pathway implicating largely a post-transcriptional regulatory mechanism.
Formal Description
Interaction-ID: 11516

drug/chemical compound

Genistein

decreases_activity of

Drugbank entries Show/Hide entries for Genistein
Comment All the phenolic compounds generated a specific gene expression profile, with genistein the most efficient in the downregulation of the expression, or over-expression, of inflammatory genes notably those linked to the arachidonic metabolism pathway. Genistein and EGCG downregulate the inflammatory response in inflamed intestinal epithelial cells by a pathway implicating largely a post-transcriptional regulatory mechanism.
Formal Description
Interaction-ID: 11517

drug/chemical compound

Epigallocatechin 3-gallate

decreases_activity of

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11518

increases_expression of

gene/protein

IFNGR1

Drugbank entries Show/Hide entries for IFNGR1
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11519

increases_expression of

gene/protein

NOD2

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11520

increases_expression of

gene/protein

TLR4

Drugbank entries Show/Hide entries for TLR4
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11521

increases_expression of

gene/protein

CCL2

Drugbank entries Show/Hide entries for CCL2
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11522

increases_expression of

gene/protein

CCL5

Drugbank entries Show/Hide entries for CCL5
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11523

increases_expression of

gene/protein

ICAM1

Drugbank entries Show/Hide entries for ICAM1
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11524

increases_expression of

gene/protein

IL1A

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11526

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11527

increases_expression of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11528

increases_expression of

gene/protein

CXCL8

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11529

increases_expression of

gene/protein

IL15

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11530

increases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11534

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11535

increases_expression of

gene/protein

NFKB1

Drugbank entries Show/Hide entries for NFKB1
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11536

increases_expression of

gene/protein

NFKB2

Drugbank entries Show/Hide entries for NFKB2
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11537

increases_expression of

gene/protein

STAT3

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11538

increases_expression of

gene/protein

SOD2

Drugbank entries Show/Hide entries for SOD2
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11540

decreases_expression of

gene/protein

CD14

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11541

decreases_expression of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11542

decreases_expression of

gene/protein

CYP3A4

Drugbank entries Show/Hide entries for CYP3A4
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11543

decreases_expression of

gene/protein

ABCG2

Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11544

decreases_expression of

gene/protein

ABCC2

Drugbank entries Show/Hide entries for ABCC2
Comment In cells incubated with the pro-inflammatory cocktail 17 genes were significantly upregulated: interferon gamma receptor 1 (INFGR1), NOD2, toll-like receptor 4 (TLR4), monocyte chemoattractant protein-1 (MCP-1, CCL2), RANTES (CCL5), ICAM1, IL-1A, IL-1B, IL-6, IL-8, IL-15, inducible nitric oxide synthase (iNOS, NOS2A), TNF alpha (TNF), NFKB1, NFKB2, STAT3, and Mn-superoxide dismutase (MnSOD, SOD2). 6 Genes were significantly downregulated: CD14, PPAR alpha (PPARA), CYP3A4, breast cancer resistance protein (BRCP, ABCG2), multi-drug resistance associated protein 2 (MRP2, ABCC2), and delta-9-desaturase (SCD).
Formal Description
Interaction-ID: 11545

decreases_expression of

gene/protein

SCD

Comment In Caco-2 cells incubated with ellagic acid IL1B expression is significantly downregulated.
Formal Description
Interaction-ID: 11551

drug/chemical compound

Ellagic acid

decreases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment In Caco-2 cells incubated with ferulic acid SCD expression is significantly downregulated.
Formal Description
Interaction-ID: 11552

drug/chemical compound

Ferulate

decreases_expression of

gene/protein

SCD

Comment In Caco-2 cells incubated with resveratrol IL1B expression is significantly downregulated.
Formal Description
Interaction-ID: 11553

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for Resveratrol or IL1B
Comment In Caco-2 cells incubated with epigallocatechin 3-gallate the expression of TNFRSF1A, STAT3, SREBF1, CYP1A1, and FASN is significantly downregulated.
Formal Description
Interaction-ID: 11554

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

TNFRSF1A

Drugbank entries Show/Hide entries for TNFRSF1A
Comment In Caco-2 cells incubated with epigallocatechin 3-gallate the expression of TNFRSF1A, STAT3, SREBF1, CYP1A1, and FASN is significantly downregulated.
Formal Description
Interaction-ID: 11562

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

STAT3

Comment In Caco-2 cells incubated with epigallocatechin 3-gallate the expression of TNFRSF1A, STAT3, SREBF1, CYP1A1, and FASN is significantly downregulated.
Formal Description
Interaction-ID: 11563

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

SREBF1

Comment In Caco-2 cells incubated with epigallocatechin 3-gallate the expression of TNFRSF1A, STAT3, SREBF1, CYP1A1, and FASN is significantly downregulated.
Formal Description
Interaction-ID: 11564

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

CYP1A1

Comment In Caco-2 cells incubated with epigallocatechin 3-gallate the expression of TNFRSF1A, STAT3, SREBF1, CYP1A1, and FASN is significantly downregulated.
Formal Description
Interaction-ID: 11565

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

FASN

Drugbank entries Show/Hide entries for FASN
Comment In Caco-2 cells incubated with genistein the expression of IL15 is significantly downregulated.
Formal Description
Interaction-ID: 11566

drug/chemical compound

Genistein

decreases_expression of

gene/protein

IL15

Drugbank entries Show/Hide entries for Genistein
Comment In Caco-2 cells incubated with chrysin the expression of IL1B, IL1R1, PPARA, ABCG2, FADS2, SCD, and SC5DL is significantly downregulated.
Formal Description
Interaction-ID: 11567

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment In Caco-2 cells incubated with chrysin the expression of IL1B, IL1R1, PPARA, ABCG2, FADS2, SCD, and SC5DL is significantly downregulated.
Formal Description
Interaction-ID: 11568

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

IL1R1

Drugbank entries Show/Hide entries for IL1R1
Comment In Caco-2 cells incubated with chrysin the expression of IL1B, IL1R1, PPARA, ABCG2, FADS2, SCD, and SC5DL is significantly downregulated.
Formal Description
Interaction-ID: 11569

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment In Caco-2 cells incubated with chrysin the expression of IL1B, IL1R1, PPARA, ABCG2, FADS2, SCD, and SC5DL is significantly downregulated.
Formal Description
Interaction-ID: 11570

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

ABCG2

Comment In Caco-2 cells incubated with chrysin the expression of IL1B, IL1R1, PPARA, ABCG2, FADS2, SCD, and SC5DL is significantly downregulated.
Formal Description
Interaction-ID: 11571

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

FADS2

Drugbank entries Show/Hide entries for FADS2
Comment In Caco-2 cells incubated with chrysin the expression of IL1B, IL1R1, PPARA, ABCG2, FADS2, SCD, and SC5DL is significantly downregulated.
Formal Description
Interaction-ID: 11572

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

SCD

Comment In Caco-2 cells incubated with chrysin the expression of IL1B, IL1R1, PPARA, ABCG2, FADS2, SCD, and SC5DL is significantly downregulated.
Formal Description
Interaction-ID: 11573

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

SC5D

Comment In Caco-2 cells incubated with curcumin the expression of IL1B, STAT3, ABCB1B, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11574

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment In Caco-2 cells incubated with curcumin the expression of IL1B, STAT3, ABCB1B, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11575

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

STAT3

Comment In Caco-2 cells incubated with curcumin the expression of IL1B, STAT3, ABCB1B, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11576

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

ABCB1

Drugbank entries Show/Hide entries for ABCB1
Comment In Caco-2 cells incubated with curcumin the expression of IL1B, STAT3, ABCB1B, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11577

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

SCD

Comment In inflamed Caco-2 cells incubated with ellagic acid the expression of CD14, IL1R1, PLA2G2A, STAT3, CYP1A1, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11578

drug/chemical compound

Ellagic acid

decreases_expression of

gene/protein

CD14

in inflamed cells
Comment In inflamed Caco-2 cells incubated with ellagic acid the expression of CD14, IL1R1, PLA2G2A, STAT3, CYP1A1, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11579

drug/chemical compound

Ellagic acid

decreases_expression of

gene/protein

IL1R1

in inflamed cells
Drugbank entries Show/Hide entries for IL1R1
Comment In inflamed Caco-2 cells incubated with ellagic acid the expression of CD14, IL1R1, PLA2G2A, STAT3, CYP1A1, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11580

drug/chemical compound

Ellagic acid

decreases_expression of

gene/protein

PLA2G2A

in inflamed cells
Drugbank entries Show/Hide entries for PLA2G2A
Comment In inflamed Caco-2 cells incubated with ellagic acid the expression of CD14, IL1R1, PLA2G2A, STAT3, CYP1A1, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11581

drug/chemical compound

Ellagic acid

decreases_expression of

gene/protein

STAT3

in inflamed cells
Comment In inflamed Caco-2 cells incubated with ellagic acid the expression of CD14, IL1R1, PLA2G2A, STAT3, CYP1A1, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11582

drug/chemical compound

Ellagic acid

decreases_expression of

gene/protein

CYP1A1

in inflamed cells
Comment In inflamed Caco-2 cells incubated with ellagic acid the expression of CD14, IL1R1, PLA2G2A, STAT3, CYP1A1, and SCD is significantly downregulated.
Formal Description
Interaction-ID: 11583

drug/chemical compound

Ellagic acid

decreases_expression of

gene/protein

SCD

in inflamed cells
Comment In inflamed Caco-2 cells incubated with ferulic acid the expression of PTGS1 is significantly downregulated.
Formal Description
Interaction-ID: 11584

drug/chemical compound

Ferulate

decreases_expression of

gene/protein

PTGS1

in inflamed cells
Drugbank entries Show/Hide entries for PTGS1
Comment In inflamed Caco-2 cells incubated with resveratrol the expression of IL6, PTGS1, and OCLN is significantly downregulated.
Formal Description
Interaction-ID: 11585

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

IL6

in inflamed cells
Drugbank entries Show/Hide entries for Resveratrol or IL6
Comment In inflamed Caco-2 cells incubated with resveratrol the expression of IL6, PTGS1, and OCLN is significantly downregulated.
Formal Description
Interaction-ID: 11586

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

PTGS1

in inflamed cells
Drugbank entries Show/Hide entries for Resveratrol or PTGS1
Comment In inflamed Caco-2 cells incubated with resveratrol the expression of IL6, PTGS1, and OCLN is significantly downregulated.
Formal Description
Interaction-ID: 11587

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

OCLN

in inflamed cells
Drugbank entries Show/Hide entries for Resveratrol
Comment In inflamed Caco-2 cells incubated with epigallocatechin 3-gallate the expression of IL1B and PTGS1 us significantly downregulated.
Formal Description
Interaction-ID: 11588

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

IL1B

in inflamed cells
Drugbank entries Show/Hide entries for IL1B
Comment In inflamed Caco-2 cells incubated with epigallocatechin 3-gallate the expression of IL1B and PTGS1 us significantly downregulated.
Formal Description
Interaction-ID: 11589

drug/chemical compound

Epigallocatechin 3-gallate

decreases_expression of

gene/protein

PTGS1

in inflamed cells
Drugbank entries Show/Hide entries for PTGS1
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11590

drug/chemical compound

Genistein

decreases_expression of

gene/protein

HLA-DRA

in inflamed cells
Drugbank entries Show/Hide entries for Genistein
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11591

drug/chemical compound

Genistein

decreases_expression of

gene/protein

IL1B

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or IL1B
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11592

drug/chemical compound

Genistein

decreases_expression of

gene/protein

NOS2

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or NOS2
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11593

drug/chemical compound

Genistein

decreases_expression of

gene/protein

PLA2G2A

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or PLA2G2A
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11594

drug/chemical compound

Genistein

decreases_expression of

gene/protein

PTGS1

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or PTGS1
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11595

drug/chemical compound

Genistein

decreases_expression of

gene/protein

TGFB1

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or TGFB1
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11596

drug/chemical compound

Genistein

decreases_expression of

gene/protein

NFKBIA

in inflamed cells
Drugbank entries Show/Hide entries for Genistein
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11597

drug/chemical compound

Genistein

decreases_expression of

gene/protein

STAT3

in inflamed cells
Drugbank entries Show/Hide entries for Genistein
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11598

drug/chemical compound

Genistein

decreases_expression of

gene/protein

OCLN

in inflamed cells
Drugbank entries Show/Hide entries for Genistein
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11599

drug/chemical compound

Genistein

decreases_expression of

gene/protein

FADS2

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or FADS2
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11600

drug/chemical compound

Genistein

decreases_expression of

gene/protein

SCD

in inflamed cells
Drugbank entries Show/Hide entries for Genistein
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11601

drug/chemical compound

Genistein

decreases_expression of

gene/protein

SC5D

in inflamed cells
Drugbank entries Show/Hide entries for Genistein
Comment In inflamed Caco-2 cells incubated with genistein the expression of HLA-DRA, IL1B, NOS2A, PLA2G2A, PTGS1, TGFB1, NFKBIA, STAT3, OCLN, FADS2, SCD, SC5DL, and SOD2 is significantly downregulated.
Formal Description
Interaction-ID: 11602

drug/chemical compound

Genistein

decreases_expression of

gene/protein

SOD2

in inflamed cells
Drugbank entries Show/Hide entries for Genistein or SOD2
Comment In inflamed Caco-2 cells incubated with chrysin the expression of HLA-DRA, IL6, IL15, FADS2, and SCD is significantly downregulated and the expression of CYP1A1 is significantly upregulated.
Formal Description
Interaction-ID: 11603

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

HLA-DRA

in inflamed cells
Comment In inflamed Caco-2 cells incubated with chrysin the expression of HLA-DRA, IL6, IL15, FADS2, and SCD is significantly downregulated and the expression of CYP1A1 is significantly upregulated.
Formal Description
Interaction-ID: 11604

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

IL6

in inflamed cells
Drugbank entries Show/Hide entries for IL6
Comment In inflamed Caco-2 cells incubated with chrysin the expression of HLA-DRA, IL6, IL15, FADS2, and SCD is significantly downregulated and the expression of CYP1A1 is significantly upregulated.
Formal Description
Interaction-ID: 11605

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

IL15

in inflamed cells
Comment In inflamed Caco-2 cells incubated with chrysin the expression of HLA-DRA, IL6, IL15, FADS2, and SCD is significantly downregulated and the expression of CYP1A1 is significantly upregulated.
Formal Description
Interaction-ID: 11606

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

FADS2

in inflamed cells
Drugbank entries Show/Hide entries for FADS2
Comment In inflamed Caco-2 cells incubated with chrysin the expression of HLA-DRA, IL6, IL15, FADS2, and SCD is significantly downregulated and the expression of CYP1A1 is significantly upregulated.
Formal Description
Interaction-ID: 11607

drug/chemical compound

Chrysin

decreases_expression of

gene/protein

SCD

in inflamed cells
Comment In inflamed Caco-2 cells incubated with chrysin the expression of HLA-DRA, IL6, IL15, FADS2, and SCD is significantly downregulated and the expression of CYP1A1 is significantly upregulated.
Formal Description
Interaction-ID: 11608

drug/chemical compound

Chrysin

increases_expression of

gene/protein

CYP1A1

in inflamed cells
Comment In inflamed Caco-2 cells incubated with quercetin the expression of NOS2A and PLA2G2A is significantly downregulated.
Formal Description
Interaction-ID: 11609

drug/chemical compound

Quercetin

decreases_expression of

gene/protein

NOS2

in inflamed cells
Drugbank entries Show/Hide entries for Quercetin or NOS2
Comment In inflamed Caco-2 cells incubated with quercetin the expression of NOS2A and PLA2G2A is significantly downregulated.
Formal Description
Interaction-ID: 11610

drug/chemical compound

Quercetin

decreases_expression of

gene/protein

PLA2G2A

in inflamed cells
Drugbank entries Show/Hide entries for Quercetin or PLA2G2A
Comment In inflamed Caco-2 cells incubated with curcumin the expression of PTGS1, CYP1A1, and CYP3A4 is significantly downregulated.
Formal Description
Interaction-ID: 11611

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

PTGS1

in inflamed cells
Drugbank entries Show/Hide entries for PTGS1
Comment In inflamed Caco-2 cells incubated with curcumin the expression of PTGS1, CYP1A1, and CYP3A4 is significantly downregulated.
Formal Description
Interaction-ID: 11612

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

CYP1A1

in inflamed cells
Comment In inflamed Caco-2 cells incubated with curcumin the expression of PTGS1, CYP1A1, and CYP3A4 is significantly downregulated.
Formal Description
Interaction-ID: 11613

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

CYP3A4

in inflamed cells
Drugbank entries Show/Hide entries for CYP3A4
Comment CD14, IFNGR1, NOD2, TLR4, CCL2, CCL5, HLA-DRA, ICAM1, IL1A, IL1B, IL6, IL8, IL15, NOS2A, PLA2G2A, IL1R1, TNFRSF1A, PTGS1, TGFB1, NFKBIA, and TNF are involved in inflammation.
Formal Description
Interaction-ID: 11614

gene/protein

CD14

affects_activity of

Comment CD14, IFNGR1, NOD2, TLR4, CCL2, CCL5, HLA-DRA, ICAM1, IL1A, IL1B, IL6, IL8, IL15, NOS2A, PLA2G2A, IL1R1, TNFRSF1A, PTGS1, TGFB1, NFKBIA, and TNF are involved in inflammation.
Formal Description
Interaction-ID: 11615

gene/protein

IFNGR1

affects_activity of

Drugbank entries Show/Hide entries for IFNGR1
Comment CD14, IFNGR1, NOD2, TLR4, CCL2, CCL5, HLA-DRA, ICAM1, IL1A, IL1B, IL6, IL8, IL15, NOS2A, PLA2G2A, IL1R1, TNFRSF1A, PTGS1, TGFB1, NFKBIA, and TNF are involved in inflammation.
Formal Description
Interaction-ID: 11616

gene/protein

NOD2

affects_activity of

Comment CD14, IFNGR1, NOD2, TLR4, CCL2, CCL5, HLA-DRA, ICAM1, IL1A, IL1B, IL6, IL8, IL15, NOS2A, PLA2G2A, IL1R1, TNFRSF1A, PTGS1, TGFB1, NFKBIA, and TNF are involved in inflammation.
Formal Description
Interaction-ID: 11617

gene/protein

TLR4

affects_activity of

Drugbank entries Show/Hide entries for TLR4
Comment CD14, IFNGR1, NOD2, TLR4, CCL2, CCL5, HLA-DRA, ICAM1, IL1A, IL1B, IL6, IL8, IL15, NOS2A, PLA2G2A, IL1R1, TNFRSF1A, PTGS1, TGFB1, NFKBIA, and TNF are involved in inflammation.
Formal Description
Interaction-ID: 11618

gene/protein

CCL2

affects_activity of

Drugbank entries Show/Hide entries for CCL2
Comment CD14, IFNGR1, NOD2, TLR4, CCL2, CCL5, HLA-DRA, ICAM1, IL1A, IL1B, IL6, IL8, IL15, NOS2A, PLA2G2A, IL1R1, TNFRSF1A, PTGS1, TGFB1, NFKBIA, and TNF are involved in inflammation.
Formal Description
Interaction-ID: 11619

gene/protein

CCL5

affects_activity of

Drugbank entries Show/Hide entries for CCL5
Comment CD14, IFNGR1, NOD2, TLR4, CCL2, CCL5, HLA-DRA, ICAM1, IL1A, IL1B, IL6, IL8, IL15, NOS2A, PLA2G2A, IL1R1, TNFRSF1A, PTGS1, TGFB1, NFKBIA, and TNF are involved in inflammation.
Formal Description
Interaction-ID: 11620

gene/protein

HLA-DRA