General Information:

Id: 1,582 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse
BTO:0001976 Neuro-2a cell
article
Reference: Manczak M et al.(2006) Mitochondria are a direct site of A beta accumulation in Alzheimers disease neurons: implications for free radical generation and oxidative damage in disease progression Hum. Mol. Genet. 15: 1437-1449 [PMID: 16551656]

Interaction Information:

Comment Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for the production of hydrogen peroxide in AD progression in Tg2576 mice.
Formal Description
Interaction-ID: 11381

organism model

Tg2576 mouse

increases_quantity of

drug/chemical compound

H2O2

Comment Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for he production of hydrogen peroxide in AD progression in Tg2576 mice.
Formal Description
Interaction-ID: 11395

increases_quantity of

drug/chemical compound

H2O2

Comment Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for the production of hydrogen peroxide in AD progression in Tg2576 mice.
Formal Description
Interaction-ID: 11396

drug/chemical compound

H2O2

increases_activity of