General Information:

Id: 1,582
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse
BTO:0001976 Neuro-2a cell
article
Reference: Manczak M et al.(2006) Mitochondria are a direct site of A beta accumulation in Alzheimers disease neurons: implications for free radical generation and oxidative damage in disease progression Hum. Mol. Genet. 15: 1437-1449 [PMID: 16551656]

Interaction Information:

Comment Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for the production of hydrogen peroxide in AD progression in Tg2576 mice.
Formal Description
Interaction-ID: 11381

organism model

Tg2576 mouse

increases_quantity of

drug/chemical compound

H2O2

Comment Cytochrome c oxidase activity was found to be decreased in Tg2576 mice when compared with age-matched WT littermates, suggesting that mutant APP and soluble Abeta impair mitochondrial metabolism in AD development and progression.
Formal Description
Interaction-ID: 11386

organism model

Tg2576 mouse

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex IV

Comment Abbeta (1-40) and Abeta (1-42) bands were found in isolated mitochondria from the cortical tissues of the Tg2576 mice. Abeta is primarily localized to the mitoplast (inner membrane plus matrix).
Formal Description
Interaction-ID: 11388

is localized in

cellular component

mitochondrial matrix

Comment Abbeta (1-40) and Abeta (1-42) bands were found in isolated mitochondria from the cortical tissues of the Tg2576 mice. Abeta is primarily localized to the mitoplast (inner membrane plus matrix).
Formal Description
Interaction-ID: 11391

is localized in

cellular component

mitochondrial matrix

Comment Abbeta (1-40) and Abeta (1-42) bands were found in isolated mitochondria from the cortical tissues of the Tg2576 mice. Abeta is primarily localized to the mitoplast (inner membrane plus matrix).
Formal Description
Interaction-ID: 11393

is localized in

cellular component

mitochondrial inner membrane

Comment Abbeta (1-40) and Abeta (1-42) bands were found in isolated mitochondria from the cortical tissues of the Tg2576 mice. Abeta is primarily localized to the mitoplast (inner membrane plus matrix).
Formal Description
Interaction-ID: 11394

is localized in

cellular component

mitochondrial inner membrane

Comment Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for he production of hydrogen peroxide in AD progression in Tg2576 mice.
Formal Description
Interaction-ID: 11395

increases_quantity of

drug/chemical compound

H2O2

Comment Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for the production of hydrogen peroxide in AD progression in Tg2576 mice.
Formal Description
Interaction-ID: 11396

drug/chemical compound

H2O2

increases_activity of

Comment Immunofluorescence analysis revealed no Abeta deposits in the 2-month-old Tg2576 mice, very few in the 8-month-old Tg2576 mice and an abundance in the 17-month-old.
Formal Description
Interaction-ID: 11398

process

aging

increases_quantity of

Comment Immunofluorescence analysis revealed no Abeta deposits in the 2-month-old Tg2576 mice, very few in the 8-month-old Tg2576 mice and an abundance in the 17-month-old.
Formal Description
Interaction-ID: 11406

organism model

Tg2576 mouse

increases_activity of

Comment In the 2-month-old Tg2576 mice, we detected both soluble Abeta (1-40) and Abeta (1-42) intraneuronally, but no insoluble Abeta. In the 12-month-old Tg2576 mice, we found both soluble and insoluble Abeta, and in the 17-month-old Tg2576 mice, we found increased levels of both soluble and insoluble Abeta.
Formal Description
Interaction-ID: 11410

organism model

Tg2576 mouse

increases_quantity of

Comment In the 2-month-old Tg2576 mice, we detected both soluble Abeta (1-40) and Abeta (1-42) intraneuronally, but no insoluble Abeta. In the 12-month-old Tg2576 mice, we found both soluble and insoluble Abeta, and in the 17-month-old Tg2576 mice, we found increased levels of both soluble and insoluble Abeta.
Formal Description
Interaction-ID: 11412

increases_quantity of

Comment Immunofluorescence analysis revealed no Abeta deposits in the 2-month-old Tg2576 mice, very few in the 8-month-old Tg2576 mice and an abundance in the 17-month-old.
Formal Description
Interaction-ID: 11413

increases_quantity of

Comment Cytochrome c oxidase activity was found to be decreased in Tg2576 mice when compared with age-matched WT littermates, suggesting that mutant APP and soluble Abeta impair mitochondrial metabolism in AD development and progression.
Formal Description
Interaction-ID: 11414

gene/protein mutant

APP-mut

decreases_activity of

complex/PPI

Mitochondrial respiratory chain complex IV

Comment Mutant APP and Abeta induces free radicals and oxidative DNA damage.
Formal Description
Interaction-ID: 11416

gene/protein mutant

APP-mut

increases_activity of

Comment Cytochrome c oxidase activity was found to be decreased in Tg2576 mice when compared with age-matched WT littermates, suggesting that mutant APP and soluble Abeta impair mitochondrial metabolism in AD development and progression.
Formal Description
Interaction-ID: 12289

organism model

Tg2576 mouse

affects_activity of

cellular component

mitochondrion

Comment Cytochrome c oxidase activity was found to be decreased in Tg2576 mice when compared with age-matched WT littermates, suggesting that mutant APP and soluble Abeta impair mitochondrial metabolism in AD development and progression.
Formal Description
Interaction-ID: 12300

complex/PPI

Mitochondrial respiratory chain complex IV

is localized in

cellular component

mitochondrion