General Information:

Id: 1,579 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
article
Reference: Zhang X et al.(2008) Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity Cell 135: 61-73 [PMID: 18854155]

Interaction Information:

Comment IKKbeta/NF-kappaB promotes the expression of of SOCS3, a core inhibitor of insulin and leptin signaling.
Formal Description
Interaction-ID: 11344

gene/protein

SOCS3

decreases_activity of