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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	1,579 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance Obesity - [OMIM]
Organism:	Mus musculus
Publication type:	article
Reference:	Zhang X et al.(2008) Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity Cell 135: 61-73 [PMID: 18854155]

Interaction Information:

Comment	IKKbeta/NF-kappaB promotes the expression of of SOCS3, a core inhibitor of insulin and leptin signaling.
Formal Description Interaction-ID: 11344	gene/protein SOCS3 decreases_activity of process insulin receptor signaling pathway

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