General Information:

Id: 1,579 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
article
Reference: Zhang X et al.(2008) Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity Cell 135: 61-73 [PMID: 18854155]

Interaction Information:

Comment While forced activation of hypothalamic IKKbeta/NF-kappaB interrupts central insulin/leptin signaling and actions, site- or cell-specific suppression of IKKbeta either broadly across the brain or locally within the mediobasal hypothalamus, or specifically in hypothalamic AGRP neurons significantly protects against obesity and glucose intolerance.
Formal Description
Interaction-ID: 11336

gene/protein

IKBKB

affects_activity of

Drugbank entries Show/Hide entries for IKBKB
Comment While forced activation of hypothalamic IKKbeta/NF-kappaB interrupts central insulin/leptin signaling and actions, site- or cell-specific suppression of IKKbeta either broadly across the brain or locally within the mediobasal hypothalamus, or specifically in hypothalamic AGRP neurons significantly protects against obesity and glucose intolerance.
Formal Description
Interaction-ID: 11338

complex/PPI

NF-kappaB complex

affects_activity of

Comment IKKbeta/NF-kappaB promotes the expression of of SOCS3, a core inhibitor of insulin and leptin signaling.
Formal Description
Interaction-ID: 11344

gene/protein

SOCS3

decreases_activity of