General Information:

Id: 1,576 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Young KJ and Bennett JP(2010) The mitochondrial secret(ase) of Alzheimers disease J. Alzheimers Dis. 20: S381-S400 [PMID: 20442493]

Interaction Information:

Comment Endogenously and exogenously-induced ROS overproduction increases both BACE1 and PS1 expression and activity, which are mediated through the activation of the JNK pathway and results in increased Abeta production.
Formal Description
Interaction-ID: 11354

drug/chemical compound

Reactive oxygen species

increases_expression of

gene/protein

PSEN1

if ROS is overexpressed; mediated through the activation of the JNK pathway;