General Information:

Id: 156 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Dagda RK et al.(2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284 [PMID: 19279012]

Interaction Information:

Comment Knockdown of endogenous PINK1 gave rise to mitochondrial fragmentation and increased autophagy and mitophagy, whereas stable or transient overexpression of PINK1 had the opposite effect.
Formal Description
Interaction-ID: 597

gene/protein

PINK1

decreases_activity of

process

autophagy

Comment Knockdown of PINK1 significantly increased mitochondrial superoxide generation, contributing to both mitochondrial fragmentation and autophagy.
Formal Description
Interaction-ID: 11733

drug/chemical compound

O2-

increases_activity of

process

autophagy