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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	156 (click here to show other Interactions for entry)
Diseases:	Parkinson disease
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000793 SH-SY5Y cell
Publication type:	article
Reference:	Dagda RK et al.(2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284 [PMID: 19279012]

Interaction Information:

Comment	Knockdown of PINK1 significantly increased mitochondrial superoxide generation, contributing to both mitochondrial fragmentation and autophagy.
Formal Description Interaction-ID: 11733	drug/chemical compound O2- increases_activity of process autophagy

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