General Information:

Id: 1,554
Diseases: Alzheimer disease - [OMIM]
Mus musculus
brain
article
Reference: Wang SM et al.(2010) Role of hepcidin in murine brain iron metabolism Cell. Mol. Life Sci. 67: 123-133 [PMID: 19898775]

Interaction Information:

Comment Hepcidin is an iron regulatory hormone, produced by hepatocytes in response to inflammatory stimuli, iron, and hypoxia.
Formal Description
Interaction-ID: 11092

affects_quantity of

gene/protein

HAMP

Comment Hepcidin is an iron regulatory hormone, produced by hepatocytes in response to inflammatory stimuli, iron, and hypoxia.
Formal Description
Interaction-ID: 11093

drug/chemical compound

Iron

affects_quantity of

gene/protein

HAMP

Comment Hepcidin is an iron regulatory hormone, produced by hepatocytes in response to inflammatory stimuli, iron, and hypoxia.
Formal Description
Interaction-ID: 11095

phenotype

hypoxia

affects_quantity of

gene/protein

HAMP

Comment Hepcidin is responsible for the regulation of body iron balance and recycling in mammals.
Formal Description
Interaction-ID: 11096

gene/protein

HAMP

affects_activity of

Comment Hepcidin is widely expressed in the murine brain.
Formal Description
Interaction-ID: 11097

gene/protein

HAMP

is localized in

tissue/cell line

brain

Comment Hepcidin mRNA levels increased with aging in cerebral cortex, hippocampus and striatum.
Formal Description
Interaction-ID: 11098

process

aging

increases_quantity of

gene/protein

HAMP

in cerebral cortex, hippocampus and striatum
Comment Injection of hepcidin into the lateral cerebral ventricle resulted in decreased Fpn1 protein levels in cerebral cortex, hippocampus, and striatum.
Formal Description
Interaction-ID: 11100

gene/protein

HAMP

decreases_expression of

gene/protein

SLC40A1

Comment Abnormal levels of brain iron have been reported in a number of age-related neurodegenerative disorders e.g. in Alzheimer's disease.
Formal Description
Interaction-ID: 11101

cooccurs with

Comment Abnormal levels of brain iron have been reported in a number of age-related neurodegenerative disorders e.g. in Alzheimer's disease.
Formal Description
Interaction-ID: 11103

affects_activity of

Comment Hepcidin is an iron regulatory hormone, produced by hepatocytes in response to inflammatory stimuli, iron, and hypoxia.
Formal Description
Interaction-ID: 11104

affects_activity of