General Information:

Id: 154
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Kuroda Y et al.(2006) Parkin enhances mitochondrial biogenesis in proliferating cells. Hum. Mol. Genet. 15: 883-895 [PMID: 16449237]

Interaction Information:

Comment Parkin is localized in mitochondria of proliferating cells and moved to the cytoplasm when cells were placed under a differentiated or quiescent condition.
Formal Description
Interaction-ID: 577

gene/protein

PARK2

is localized in

cellular component

mitochondrion

in proliferating cells
Comment Parkin is localized in mitochondria of proliferating cells and moved to the cytoplasm when cells were placed under a differentiated or quiescent condition.
Formal Description
Interaction-ID: 578

gene/protein

PARK2

is localized in

cellular component

cytoplasm

in differentiated or quiescent cells
Comment Parkin interacts with TFAM in mitochondria and enhances TFAM-mediated mitochondrial transcription.
Formal Description
Interaction-ID: 590

gene/protein

PARK2

interacts (colocalizes) with

gene/protein

TFAM

in mitochondria
Comment Parkin interacts with TFAM in mitochondria and enhances TFAM-mediated mitochondrial transcription.
Formal Description
Interaction-ID: 9354

gene/protein

PARK2

increases_activity of

gene/protein

TFAM

in mitochondria; thus increasing transcription activity in mitochondria