General Information:

Id: 1,547
Diseases: Parkinson disease
Homo sapiens
BTO:0000143 substantia nigra
article
Reference: Zheng B et al.(2010) PGC-1alpha, a potential therapeutic target for early intervention in Parkinsons disease Sci Transl Med 2: 52RA73 [PMID: 20926834]

Interaction Information:

Comment The transcriptional coactivator PPARGC1A (PGC-1alpha) is a master regulator of mitochondrial biogenesis and oxidative metabolism.
Formal Description
Interaction-ID: 11054

gene/protein

PPARGC1A

affects_activity of

process

mitochondrion organization

Comment PGC-1alpha overexpression suppresses dopaminergic neuron loss induced by A53T-synuclein and rotenone.
Formal Description
Interaction-ID: 11055

gene/protein

PPARGC1A

decreases_activity of

process

neuron death

if neuron death has been induced by SNCA overexpression or rotenone
Comment PGC-1alpha overexpression suppresses dopaminergic neuron loss induced by A53T-synuclein and rotenone.
Formal Description
Interaction-ID: 11056

gene/protein

PPARGC1A

decreases_activity of

gene/protein mutant

SNCA-p.A53T

if neuron death has been induced by SNCA-A53T
Comment Overexpression of PGC-1alpha coactivated the expression of nuclear-encoded subunits of complex I, II, III, IV, and V of the mitochondrial ETC.
Formal Description
Interaction-ID: 11058

gene/protein

PPARGC1A

increases_activity of

complex/PPI

Mitochondrial respiratory chain

Comment Genes controlling cellular bioenergetics that are expressed in response to PGC-1alpha are underexpressed in Parkinson’s disease patients.
Formal Description
Interaction-ID: 11060

disease

Parkinson disease

decreases_activity of

gene/protein

PPARGC1A