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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	1,538
Diseases:	Parkinson disease
Organism:	Mammalia
Tissue/Cell line:	BTO:0004476 MES-23.5 cell
Publication type:	article
Reference:	Xu H et al.(2010) Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells J. Cell. Biochem. 111: 1537-1545 [PMID: 20872781]

Interaction Information:

Comment	Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect iron-induced damage of dopamine neurons.
Formal Description Interaction-ID: 10975	drug/chemical compound Iron increases_activity of process mitochondrial depolarization by decreasing the mitochondrial membrane potential

Comment	Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect iron-induced damage of dopamine neurons.
Formal Description Interaction-ID: 10976	drug/chemical compound Ginsenoside Rg1 decreases_activity of process mitochondrial depolarization if the membrane potential has been decreased by iron

Comment	Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect iron-induced damage of dopamine neurons.
Formal Description Interaction-ID: 10977	drug/chemical compound Iron increases_activity of process neuron death by decreasing the mitochondrial membrane potential

Comment	Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect iron-induced damage of dopamine neurons.
Formal Description Interaction-ID: 10978	drug/chemical compound Ginsenoside Rg1 decreases_activity of process neuron death if neuron death has been induced by iron

Comment	Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect could protect iron-induced damage of dopamine neurons.
Formal Description Interaction-ID: 10979	drug/chemical compound Ginsenoside Rg1 decreases_activity of drug/chemical compound Iron by decreasing iron-induced mitochondrial membrane depolarisation

Comment	6-OHDA induces an increase in iron influx.
Formal Description Interaction-ID: 10980	drug/chemical compound 6-OHDA increases_quantity of drug/chemical compound Iron by increasing iron influx

Comment	Rg1 treatment prevented ferrous iron influx in 6-OHDA treated MES23.5 cells.
Formal Description Interaction-ID: 10981	drug/chemical compound Ginsenoside Rg1 decreases_quantity of drug/chemical compound Iron by decreasing 6-OHDA-induced iron influx

Comment	There was a 2.41-fold increase of DMT1+IRE mRNA in 6-OHDA treated cells. Pretreatment with Rg1 reversed the increase of DMT1+IRE mRNA.
Formal Description Interaction-ID: 10982	drug/chemical compound 6-OHDA increases_expression of gene/protein SLC11A2

Comment	There was a 2.41-fold increase of DMT1+IRE mRNA in 6-OHDA treated cells. Pretreatment with Rg1 reversed the increase of DMT1+IRE mRNA.
Formal Description Interaction-ID: 10983	drug/chemical compound Ginsenoside Rg1 decreases_expression of gene/protein SLC11A2 if expression has been induced by 6-OHDA

Comment	DMT1 is a ferrous iron importer protein.
Formal Description Interaction-ID: 10984	gene/protein SLC11A2 increases_quantity of drug/chemical compound Iron by increasing the import of iron

Comment	DMT1 is a ferrous iron importer protein.
Formal Description Interaction-ID: 10985	gene/protein SLC11A2 increases_transport of drug/chemical compound Iron by increasing the import of iron

Comment	Both IRP1 and IRP2 were up-regulated in mRNA and protein levels after 6-OHDA treatment compared to the control.
Formal Description Interaction-ID: 10986	drug/chemical compound 6-OHDA increases_expression of gene/protein ACO1

Comment	Both IRP1 and IRP2 were up-regulated in mRNA and protein levels after 6-OHDA treatment compared to the control.
Formal Description Interaction-ID: 10987	drug/chemical compound 6-OHDA increases_expression of gene/protein IREB2

Comment	After Rg1 pretreatment the mRNA and protein levels of IRPs restored to the levels of control.
Formal Description Interaction-ID: 10988	drug/chemical compound Ginsenoside Rg1 decreases_quantity of gene/protein ACO1

Comment	After Rg1 pretreatment the mRNA and protein levels of IRPs restored to the levels of control.
Formal Description Interaction-ID: 10989	drug/chemical compound Ginsenoside Rg1 decreases_quantity of gene/protein IREB2

Comment	Both IRP1 and IRP2 were up-regulated in mRNA and protein levels after 6-OHDA treatment compared to the control.
Formal Description Interaction-ID: 10990	drug/chemical compound 6-OHDA increases_quantity of gene/protein ACO1

Comment	Both IRP1 and IRP2 were up-regulated in mRNA and protein levels after 6-OHDA treatment compared to the control.
Formal Description Interaction-ID: 10991	drug/chemical compound 6-OHDA increases_quantity of gene/protein IREB2

Comment	IRPs are RNA-binding proteins that affect the translation and stabilization of specific mRNAs, like DMT1, by binding to IREs in iron related proteins and maintain the iron levels.
Formal Description Interaction-ID: 10992	gene/protein ACO1 affects_activity of gene/protein SLC11A2

Comment	IRPs are RNA-binding proteins that affect the translation and stabilization of specific mRNAs, like DMT1, by binding to IREs in iron related proteins and maintain the iron levels.
Formal Description Interaction-ID: 10993	gene/protein IREB2 affects_activity of gene/protein SLC11A2

Comment	6-OHDA is a neurotoxin to produce PD models, which could create oxidative stress through the production of hydrogen peroxide and other ROS.
Formal Description Interaction-ID: 10994	drug/chemical compound 6-OHDA increases_activity of disease Parkinson disease

Comment	ROS in 6-OHDA treated MES23.5 cells was significantly increased compared with control, pretreatment with Rg1 decreased 6-OHDA-induced ROS production.
Formal Description Interaction-ID: 10995	drug/chemical compound 6-OHDA increases_quantity of drug/chemical compound Reactive oxygen species

Comment	ROS in 6-OHDA treated MES23.5 cells was significantly increased compared with control, pretreatment with Rg1 decreased 6-OHDA-induced ROS production.
Formal Description Interaction-ID: 10996	drug/chemical compound Ginsenoside Rg1 decreases_quantity of drug/chemical compound Reactive oxygen species

Comment	Rg1 treatment prevented ferrous iron influx in 6-OHDA treated MES23.5 cells.
Formal Description Interaction-ID: 11109	drug/chemical compound Ginsenoside Rg1 affects_activity of process iron ion homeostasis by decreasing 6-OHDA-induced iron influx

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