General Information:
Id: | 1,538 |
Diseases: |
Parkinson disease
|
Mammalia | |
BTO:0004476 MES-23.5 cell | |
article | |
Reference: | Xu H et al.(2010) Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells J. Cell. Biochem. 111: 1537-1545 [PMID: 20872781] |
Interaction Information:
Comment | Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect iron-induced damage of dopamine neurons. |
Formal Description Interaction-ID: 10975 |
drug/chemical compound increases_activity of process |
Comment | Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect iron-induced damage of dopamine neurons. |
Formal Description Interaction-ID: 10976 |
drug/chemical compound decreases_activity of process |
Comment | Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect iron-induced damage of dopamine neurons. |
Formal Description Interaction-ID: 10977 |
drug/chemical compound increases_activity of process |
Comment | Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect iron-induced damage of dopamine neurons. |
Formal Description Interaction-ID: 10978 |
drug/chemical compound decreases_activity of process |
Comment | Iron treatment decreased the mitochondrial membrane potential. Rg1 pretreatment could restore the mitochondrial membrane potential to the control. This indicated Rg1 could protect could protect iron-induced damage of dopamine neurons. |
Formal Description Interaction-ID: 10979 |
drug/chemical compound decreases_activity of drug/chemical compound |
Comment | 6-OHDA induces an increase in iron influx. |
Formal Description Interaction-ID: 10980 |
drug/chemical compound 6-OHDA increases_quantity of drug/chemical compound |
Comment | Rg1 treatment prevented ferrous iron influx in 6-OHDA treated MES23.5 cells. |
Formal Description Interaction-ID: 10981 |
drug/chemical compound decreases_quantity of drug/chemical compound |
Comment | There was a 2.41-fold increase of DMT1+IRE mRNA in 6-OHDA treated cells. Pretreatment with Rg1 reversed the increase of DMT1+IRE mRNA. |
Formal Description Interaction-ID: 10982 |
|
Comment | There was a 2.41-fold increase of DMT1+IRE mRNA in 6-OHDA treated cells. Pretreatment with Rg1 reversed the increase of DMT1+IRE mRNA. |
Formal Description Interaction-ID: 10983 |
drug/chemical compound decreases_expression of gene/protein |
Comment | DMT1 is a ferrous iron importer protein. |
Formal Description Interaction-ID: 10984 |
|
Comment | DMT1 is a ferrous iron importer protein. |
Formal Description Interaction-ID: 10985 |
|
Comment | Both IRP1 and IRP2 were up-regulated in mRNA and protein levels after 6-OHDA treatment compared to the control. |
Formal Description Interaction-ID: 10986 |
|
Comment | Both IRP1 and IRP2 were up-regulated in mRNA and protein levels after 6-OHDA treatment compared to the control. |
Formal Description Interaction-ID: 10987 |
|
Comment | After Rg1 pretreatment the mRNA and protein levels of IRPs restored to the levels of control. |
Formal Description Interaction-ID: 10988 |
|
Comment | After Rg1 pretreatment the mRNA and protein levels of IRPs restored to the levels of control. |
Formal Description Interaction-ID: 10989 |
|
Comment | Both IRP1 and IRP2 were up-regulated in mRNA and protein levels after 6-OHDA treatment compared to the control. |
Formal Description Interaction-ID: 10990 |
|
Comment | Both IRP1 and IRP2 were up-regulated in mRNA and protein levels after 6-OHDA treatment compared to the control. |
Formal Description Interaction-ID: 10991 |
|
Comment | IRPs are RNA-binding proteins that affect the translation and stabilization of specific mRNAs, like DMT1, by binding to IREs in iron related proteins and maintain the iron levels. |
Formal Description Interaction-ID: 10992 |
|
Comment | IRPs are RNA-binding proteins that affect the translation and stabilization of specific mRNAs, like DMT1, by binding to IREs in iron related proteins and maintain the iron levels. |
Formal Description Interaction-ID: 10993 |
|
Comment | 6-OHDA is a neurotoxin to produce PD models, which could create oxidative stress through the production of hydrogen peroxide and other ROS. |
Formal Description Interaction-ID: 10994 |
drug/chemical compound 6-OHDA increases_activity of disease Parkinson disease |
Comment | ROS in 6-OHDA treated MES23.5 cells was significantly increased compared with control, pretreatment with Rg1 decreased 6-OHDA-induced ROS production. |
Formal Description Interaction-ID: 10995 |
drug/chemical compound 6-OHDA increases_quantity of drug/chemical compound Reactive oxygen species |
Comment | ROS in 6-OHDA treated MES23.5 cells was significantly increased compared with control, pretreatment with Rg1 decreased 6-OHDA-induced ROS production. |
Formal Description Interaction-ID: 10996 |
drug/chemical compound decreases_quantity of drug/chemical compound Reactive oxygen species |
Comment | Rg1 treatment prevented ferrous iron influx in 6-OHDA treated MES23.5 cells. |
Formal Description Interaction-ID: 11109 |
drug/chemical compound affects_activity of process |