General Information:

Id: 1,520 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Jo DG et al.(2010) Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimers disease Neurobiol. Aging 31: 917-925 [PMID: 18687504]

Interaction Information:

Comment Oxidative stress-induced BACE1 expression is reduced in presenilin-1-deficient cells.
Formal Description
Interaction-ID: 10790

gene/protein

PSEN1

increases_expression of

gene/protein

BACE1

Oxidative stress-induced BACE1 expression is reduced in presenilin-1 (gamma-secretase)-deficient cells.
Drugbank entries Show/Hide entries for BACE1
Comment Oxidative stress-induced BACE1 expression is reduced in presenilin-1-(gamma-secretase)-deficient cells.
Formal Description
Interaction-ID: 10792

gene/protein

PSEN1

increases_activity of

complex/PPI

Gamma-secretase complex

Oxidative stress-induced BACE1 expression is reduced in presenilin-1 (gamma-secretase)-deficient cells.