General Information:

Id: 152
Diseases: Parkinson disease
Homo sapiens
BTO:0000932 neuroblastoma cell line; BE(2)C cell
article
Reference: Kim Y et al.(2008) PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 377: 975-980 [PMID: 18957282]

Interaction Information:

Comment PINK1 induces Parkin localization to mitochondria by phosphorylation of Parkin. For this translocation of Parkin into mitochondria an intact RING1 domain of Parkin is required. Parkin mutant C238S, lacking the RING1 domain, is not localized in mitochondria.
Formal Description
Interaction-ID: 571

gene/protein

PINK1

increases_transport of

gene/protein

PARK2

into mitochondria; by phosphorylation of PARK2
Comment PINK1 induces Parkin localization to mitochondria by phosphorylation of Parkin. For this translocation of Parkin into mitochondria an intact RING1 domain of Parkin is required. Parkin mutant C238S, lacking the RING1 domain, is not localized in mitochondria.
Formal Description
Interaction-ID: 575

gene/protein

PINK1

NOT increases_transport of

gene/protein mutant

PARK2-p.C238S

into mitochondria
Comment PINK1 induces Parkin localization to mitochondria by phosphorylation of Parkin. For this translocation of Parkin into mitochondria an intact RING1 domain of Parkin is required. Parkin mutant C238S, lacking the RING1 domain, is not localized in mitochondria.
Formal Description
Interaction-ID: 4052

gene/protein

PINK1

increases_phosphorylation of

gene/protein

PARK2