General Information:

Id: 151 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mammalia
BTO:0001976 Neuro-2a cell
article
Reference: Oh YK et al.(2008) Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells J. Neurochem. 104: 993-1005 [PMID: 18233996]

Interaction Information:

Comment Mutant SOD1 induced cleavage of ATF6 into 50 kDa fragments and its translocation into the nucleus when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 601

gene/protein mutant

SOD1-p.G93A

increases_transport of

gene/protein

ATF6

into nucleus; if mutant SOD1 is over-expressed