General Information:

Id: 1,519 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
ob/ob mouse
article
Reference: Gonzalez-Periz A et al.(2009) Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins FASEB J. 23: 1946-1957 [PMID: 19211925]

Interaction Information:

Comment The antisteatotic effect was associated with changes in the expression of genes governing hepatic lipogenesis and fatty acid oxidation. Omega-3-PUFAs down-regulated FASN, a lipogenic factor, and up-regulated PPAR-alpha, a transcription factor that functions as a gatekeeper of fatty acid oxidation. The expression of SREBP-1c and SCD-1 remained unchanged.
Formal Description
Interaction-ID: 10771

drug/chemical compound

Polyunsaturated fatty acid, omega-3

affects_activity of

in liver