General Information:

Id: 1,518 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
high-fat diet-induced obese and leptin-deficient ob/ob male C57BL/6J mouse
article
Reference: Weisberg SP et al.(2008) Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity Endocrinology 149: 3549-3558 [PMID: 18403477]

Interaction Information:

Comment In liver curcumin significantly decreased the expression of TNF-alpha, suppressor of cytokine signaling-3 (SOCS-3), MCP-1, and chemokin (C-C motif) ligand-2 (CCR-2) in ob/ob mice.
Formal Description
Interaction-ID: 10753

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

CCR2

in liver; in ob/ob mice