General Information:

Id: 1,518
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
high-fat diet-induced obese and leptin-deficient ob/ob male C57BL/6J mouse
article
Reference: Weisberg SP et al.(2008) Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity Endocrinology 149: 3549-3558 [PMID: 18403477]

Interaction Information:

Comment Dietary curcumin admixture ameliorated diabetes in high-fat diet-induced obese and leptin-deficient ob/ob male C57BL/6J mice as determined by glucose and insulin tolerance testing and hemoglobin A1c percentages.
Formal Description
Interaction-ID: 10744

drug/chemical compound

Curcumin

decreases_activity of

in mouse models of obesity-related diabetes
Comment Curcumin reduced the number of macrophages present in the perigonadal white adipose tissue of DIO and ob/ob mice as determined by staining with a macrophage-specific F4/80 antibody.
Formal Description
Interaction-ID: 10746

drug/chemical compound

Curcumin

decreases_quantity of

tissue/cell line

macrophage

in perigonadal white adipose tissue; in mouse models of obesity-related diabetes
Comment Curcumin significantly decreased the expression of Emr1, the macrophage-specific gene encoding the F4/80 antigen, in perigonadal white adipose tissue.
Formal Description
Interaction-ID: 10747

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

EMR1

in perigonadal white adipose tissue; in mouse models of obesity-related diabetes
Comment Curcumin treatment significantly increased perigonadal adipose expression of the genes encoding the forkhead transcription factor Foxo1 and the antiinflammatory adipokine adiponectin.
Formal Description
Interaction-ID: 10748

drug/chemical compound

Curcumin

increases_expression of

gene/protein

FOXO1

in perigonadal white adipose tissue; in mouse models of obesity-related diabetes
Comment Curcumin treatment significantly increased perigonadal adipose expression of the genes encoding the forkhead transcription factor Foxo1 and the antiinflammatory adipokine adiponectin.
Formal Description
Interaction-ID: 10749

drug/chemical compound

Curcumin

increases_expression of

gene/protein

ADIPOQ

in perigonadal white adipose tissue; in mouse models of obesity-related diabetes
Comment In liver curcumin significantly decreased the expression of TNF-alpha, suppressor of cytokine signaling-3 (SOCS-3), MCP-1, and chemokin (C-C motif) ligand-2 (CCR-2) in ob/ob mice.
Formal Description
Interaction-ID: 10750

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

TNF

in liver; in ob/ob mice
Drugbank entries Show/Hide entries for TNF
Comment In liver curcumin significantly decreased the expression of TNF-alpha, suppressor of cytokine signaling-3 (SOCS-3), MCP-1, and chemokin (C-C motif) ligand-2 (CCR-2) in ob/ob mice.
Formal Description
Interaction-ID: 10751

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

SOCS3

in liver; in ob/ob mice
Comment In liver curcumin significantly decreased the expression of TNF-alpha, suppressor of cytokine signaling-3 (SOCS-3), MCP-1, and chemokin (C-C motif) ligand-2 (CCR-2) in ob/ob mice.
Formal Description
Interaction-ID: 10752

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

CCL2

in liver; in ob/ob mice
Drugbank entries Show/Hide entries for CCL2
Comment In liver curcumin significantly decreased the expression of TNF-alpha, suppressor of cytokine signaling-3 (SOCS-3), MCP-1, and chemokin (C-C motif) ligand-2 (CCR-2) in ob/ob mice.
Formal Description
Interaction-ID: 10753

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

CCR2

in liver; in ob/ob mice
Comment Curcumin treatment significantly reduced markers of hepatic inflammation.
Formal Description
Interaction-ID: 10754

drug/chemical compound

Curcumin

decreases_activity of

in liver